儿童社区获得性肺炎易感性和治疗效果与人类白细胞抗原Ⅱ、核因子κB基因多态性的关系  

Relationship between susceptibility and treatment effect of community-acquired pneumonia in children and polymorphisms of human leukocyte antigenⅡand nuclear factorκB gene

作　　者：王梦莹 杨帆 孟伟 Wang Mengying;Yang Fan;Meng Wei(Department of Pediatrics,Baoding Second Central Hospital,Baoding 072750,China;Department of Pharmacy,Baoding Second Central Hospital,Baoding 072750,China;Department of Clinical Laboratory,Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]保定市第二中心医院儿科,保定072750 [2]保定市第二中心医院药剂科,保定072750 [3]河北大学附属医院检验科,保定071000

出　　处：《中国医师杂志》2025年第2期252-256,260,共6页Journal of Chinese Physician

摘　　要：目的研究人类白细胞抗原(HLA)Ⅱ、核因子κB(NF-κB)基因多态性与儿童社区获得性肺炎易感性及阿莫西林克拉维酸钾治疗效果的相关性。方法前瞻性选取2018年2月—2021年1月保定市第二中心医院收治的120例儿童社区获得性肺炎患儿作为研究对象(观察组),根据接受阿莫西林克拉维酸钾治疗后的效果分为有效组与无效组,另选取同期健康体检的儿童120例作为对照组,比较两组的HLAⅡ、NF-κB基因多态性,分析HLAⅡ、NF-κB基因多态性与儿童社区获得性肺炎易感性及阿莫西林克拉维酸钾治疗效果的相关性。结果观察组HLA-DQA1*0201[86(71.67%)vs 40(33.33%)]、HLA-DQA1*0301[72(60.00%)vs 20(16.67%)]基因频率明显高于对照组,HLA-DQA1*0401[30(25.00%)vs 96(80.00%)]基因频率明显低于对照组(均P<0.05)。观察组HLA-DRB1*07[92(76.67%)vs 48(40.00%)]、HLA-DRB1*15[72(60.00%)vs 40(33.33%)]、HLA-DRB1*16[96(80.00%)vs 76(63.33%)]基因频率明显高于对照组,HLA-DRB1*11[36(30.00%)vs 104(86.67%)]基因频率明显低于对照组(均P<0.05)。观察组基因-94ins/delATTG*II达明显高于对照组[40(33.33%)vs 24(20.00%),P<0.05]。无效组HLA-DQA1*0201[12(38.71%)vs 74(83.15%)]、HLA-DQA1*0301[9(29.03%)vs 63(70.79%)]基因频率明显低于有效组,HLA-DQA1*0401[18(58.06%)vs 12(13.48%)]基因频率明显高于有效组(均P<0.05)。无效组的HLA-DRB1*07[29(93.55%)vs 63(70.79%)]、HLA-DRB1*15[29(93.55%)vs 43(48.31%)]、HLA-DRB1*16[29(93.55%)vs 67(75.28%)]的基因频率明显高于有效组,HLA-DRB1*11[17(54.84%)vs 19(21.35%)]的基因频率明显高于有效组(均P<0.05)。无效组基因-94ins/delATTG*II表达明显高于有效组[15(48.39%)vs 25(28.09%),P<0.05]。结论HLAⅡ、NF-κB基因多态性与儿童社区获得性肺炎易感性及阿莫西林克拉维酸钾疗效有关。ObjectiveTo study the relationship between human leukocyte antigen(HLA)Ⅱand nuclear factorκB(NF-κB)gene polymorphisms and susceptibility to community-acquired pneumonia in children and the therapeutic effect of amoxicillin clavulanate potassium.MethodsA total of 120 children with community-acquired pneumonia admitted to the Baoding Second Central Hospital from February 2018 to January 2021 were selected as the study objects(observation group).According to the effect of amoxicillin and clavulanate potassium treatment,they were divided into effective group and ineffective group,and 120 healthy children in the same period were selected as the control group.The polymorphisms of HLAⅡand NF-κB gene were compared between the two groups,and the correlation between the polymorphisms of HLAⅡand NF-κB gene and the susceptibility of children to community-acquired pneumonia and the therapeutic effect of amoxicillin clavulanate potassium was analyzed.ResultsThe gene frequency of HLA-DQA1*0201[86(71.67%)vs 40(33.33%)],HLA-DQA1*0301[72(60.00%)vs 20(16.67%)]of the observation group was significantly higher than that of the control group,the gene frequency of HLA-DQA1*0401[30(25.00%)vs 96(80.00%)]was significantly lower than that of control group(all P<0.05).The gene frequency of HLA-DRB1*07[92(76.67%)vs 48(40.00%)],HLA-DRB1*15[72(60.00%)vs 40(33.33%)],HLA-DRB1*16[96(80.00%)vs 76(63.33%)]of the observation group was significantly higher than that of the control group,and the gene frequency of HLA-DRB1*11[36(30.00%)vs 104(86.67%)]was significantly lower than that of control group(all P<0.05).The expression of 94ins/delATTG*II in the observation group was significantly higher than that in the control group[40(33.33%)vs 24(20.00%),P<0.05].The gene frequency of HLA-DQA1*0201[12(38.71%)vs 74(83.15%)],HLA-DQA1*0301[9(29.03%)vs 63(70.79%)]in the ineffective group was significantly lower than that of the effective group,the gene frequency of HLA-DQA1*0401[18(58.06%)vs 12(13.48%)]was significantly higher than that of the effectiv

关 键 词：HLA抗原 NF-κB 基因多态性 社区获得性肺炎 儿童 

分 类 号：R73[医药卫生—肿瘤]