Fbxw7蛋白在DLBCL中表达及临床意义研究  

The Expression and Clinical Significance of Fbxw7 Protein in DLBCL

作　　者：黄文强[1,2,3] 郑雷 靳松[4] 胡松元 付云秋 张晋 龙思方 HUANG Wenqiang;ZHENG Lei;JIN Song;HU Songyuan;FU Yunqiu;ZHANG Jin;LONG Sifang(Qiannan Medical College For Nationlities,Duyun 558000,China;不详)

机构地区：[1]黔南民族医学高等专科学校,贵州都匀558000 [2]黔南民族医学高等专科学校附属匀东医院 [3]贵州中润博达司法鉴定所 [4]黔南布依族苗族自治州人民医院 [5]黔南布依族苗族自治州中医医院

出　　处：《中外医学研究》2025年第6期1-3,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：黔南民族医学高等专科学校科研骨干支撑项目(QNYZ2003005)。

摘　　要：目的:探讨Fbxw7蛋白在弥漫大B细胞淋巴瘤(DLBCL)中的表达及临床意义。方法:回顾性分析2022年1月—2024年1月黔南民族医学高等专科学校附属匀东医院收治的65例DLBCL患者及65例淋巴结反应性增生患者临床资料,将DLBCL患者设为观察组,将淋巴结反应性增生患者设为对照组。均采集病理标本开展免疫组化检测,比较两组Fbxw7蛋白表达情况并分析Fbxw7蛋白表达在不同临床特征中的变化。结果:观察组Fbxw7蛋白阳性表达率为47.69%,低于对照组的80.00%,差异有统计学意义(P<0.05)。Fbxw7阳性组肿瘤分期Ⅲ~Ⅳ期、分化程度低、有淋巴结转移占比低于阴性组,差异有统计学意义(P<0.05)。结论:Fbxw7蛋白在DLBCL中处于低表达状态,其低表达可促使肿瘤进展,使得疾病分期高、分化程度低,且易伴有淋巴结转移,明确Fbxw7蛋白表达可为疾病治疗提供新的方向。Objective:To explore the expression and clinical significance of Fbxw7 protein in diffuse large B-cell lymphoma(DLBCL).Method:Clinical datas of 65 patients with DLBCL and 65 patients with reactive lymph node hyperplasia admitted to Yundong Hospital Affiliated to Qiannan College of Ethnic Medicine from January 2022 to January 2024 were retrospectively analyzed.DLBCL patients were set as observation group,and those with reactive lymph node hyperplasia were set as control group.Pathological samples were collected for immunohistochemical detection.Fbxw7 protein expression was compared between the two groups and the changes of Fbxw7 protein expression in different clinical characteristics were analyzed.Result:The positive expression rate of Fbxw7 protein in the observation group was 47.69%,which was lower than that in the control group(80.00%),and the difference was statistically significant(P<0.05).The tumor stage of Fbxw7 positive group wasⅢ~Ⅳ,the degree of differentiation was lower,and the proportion of lymph node metastasis was lower than that of negative group,and the difference was statistically significant(P<0.05).Conclusion:Fbxw7 protein is in a low expression state in DLBCL,and its low expression can promote tumor progression,resulting in high disease stage,low differentiation,and easy to be accompanied by lymph node metastasis.Therefore,clear expression of Fbxw7 protein can provide a new direction for disease treatment.

关 键 词：弥漫大B细胞淋巴瘤 Fbxw7蛋白 临床表达 病理特征 

分 类 号：R73[医药卫生—肿瘤]