小剂量地西他滨联合放疗治疗中晚期鼻咽癌的效果  

Efficacy of Low Dose Decitabine Combined with Radiotherapy in the Treatment of Advanced Nasopharyngeal Carcinoma

作　　者：钟恒诚 滕炳祥[1] 熊春[1] 马智[1] ZHONG Hengcheng;TENG Bingxiang;XIONG Chun;MA Zhi(The First Affiliated Hospital of Guangxi University of Science and Technology,Liuzhou 545000,China;不详)

机构地区：[1]广西科技大学第一附属医院,广西柳州545000

出　　处：《中外医学研究》2025年第6期104-107,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：广西医疗卫生适宜技术开发与推广应用项目(S2018032)。

摘　　要：目的:研究小剂量地西他滨联合放疗治疗中晚期鼻咽癌的效果。方法:选取2020年1月—2021年10月广西科技大学第一附属医院收治的100例中晚期鼻咽癌患者作为研究对象,根据随机数字法分为对照组和研究组,每组各50例。对照组予以顺铂联合放疗治疗,研究组以小剂量地西他滨联合放疗治疗,两组均治疗8周,治疗后随访2年。比较两组近期疗效、放化疗前后(第8周)肿瘤退缩情况、放化疗的毒性反应和随访期内的生存率情况。结果:研究组近期治疗有效率高于对照组,差异有统计学意义(P<0.05);两组毒性反应中肝肾损伤及口腔溃疡等比较,差异无统计学意义(P>0.05),但研究组胃肠反应及血小板下降的毒性反应程度比对照组显著,差异有统计学意义(P<0.05);放化疗后(第8周)研究组的肿瘤体积退缩程度高于对照组,差异有统计学意义(P<0.05);研究组的总生存率、无疾病生存率、无远处转移生存率均优于对照组,差异有统计学意义(P<0.05)。结论:小剂量地西他滨联合放疗可提高中晚期鼻咽癌患者近期疗效,减轻毒性反应,有利于控制肿瘤体积,提高患者生存率。Objective:To study the efficacy of low-dose decitabine combined with radiotherapy in the treatment of advanced nasopharyngeal carcinoma.Method:A total of 100 patients with advanced nasopharyngeal carcinoma admitted to the First Affiliated Hospital of Guangxi University of Science and Technology from January 2020 to October 2021 were selected as research objects and divided into control group and research group according to random number method,with 50 cases in each group.The control group was treated with cisplatin combined with radiotherapy,while the study group was treated with low-dose decitabine combined with radiotherapy.Both groups were treated for 8 weeks and followed up for 2 years after treatment.The short-term efficacy,tumor regression before and after chemoradiation(the 8th week),toxicity of chemoradiation and chemotherapy,and survival rate during follow-up were compared between the two groups.Result:The short-term effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in liver and kidney injury and oral ulcer between the two groups(P>0.05).But the degree of gastrointestinal reaction and thrombocytopenia toxicity in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).After radiotherapy and chemotherapy(the 8th week),the tumor volume shrinkage of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The overall survival rate,disease-free survival rate and distant metastasis free survival rate of the study group were better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion:Low dose decitabine combined with radiotherapy can improve the short-term efficacy of patients with advanced nasopharyngeal carcinoma,reduce the toxicity of patients,control the tumor volume and improve the survival rate of patients.

关 键 词：地西他滨 顺铂 鼻咽癌 疗效 生存率 

分 类 号：R73[医药卫生—肿瘤]