前列地尔联合参麦注射液治疗急性重症胰腺炎的疗效及对血清炎症指标的影响  

Efficacy of Alprostadil Combined with Shenmai Injection in the Treatment of Acute Severe Pancreatitis and its Effect on Serum Inflammatory Markers

作　　者：田卓 马金春 TIAN Zhuo;MA Jin-chun(Department of gastroenterology,Huangshi Aikang Hospital affiliated to Hubei Institute of Technology,Huangshi Hubei 435000,China)

机构地区：[1]湖北理工学院附属黄石爱康医院消化内科,湖北黄石435000

出　　处：《湖北科技学院学报(医学版)》2025年第2期126-129,共4页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的探讨前列地尔联合参麦注射液治疗急性重症胰腺炎的疗效及对血清C反应蛋白(CRP)和降钙素原(PCT)的影响。方法选取就诊于本院的急性重症胰腺炎患者122例,利用随机数字表将其分别纳入对照组和观察组,每组61例,前者行参麦注射液治疗,后者在此基础上增加前列地尔治疗,对两组临床疗效、症状恢复、血生化结果以及不良反应进行观察和分析。结果观察组治疗总有效率同对照组相比,前者更高(90.16%VS 75.41%)(P<0.05);观察组腹痛、腹胀、恶心呕吐及胃肠功能恢复时间均较对照组短(P<0.05);两组治疗后淀粉酶(AMY)、乳酸脱氢酶(LDH)、脂肪酶(LPS)、肌酐(Cr)水平均较治疗前下降,白蛋白(ALB)、前白蛋白(PA)水平较治疗前升高,且观察组AMY、LDH、LPS、Cr水平较对照组低,ALB、PA水平较对照组高(P<0.05);观察组治疗后CRP、PCT、IL-6水平相对对照组更低(P<0.05);观察组不良反应发生率较对照组无明显差异(9.84%VS 8.20%)(P>0.05)。结论前列地尔有利于加强参麦注射液在急性重症胰腺炎中的临床疗效,改善患者临床症状、血清生化结果,且安全性好,值得临床推广。Objective To investigate the efficacy of alprostadil combined with Shenmai injection in the treatment of acute severe pancreatitis(SAP)and its effect on serum C-reactive protein(CRP)and procalcitonin(PCT).Methods 122 patients with SAP admitted to the hospital were enrolled and divided into control group and observation group by random number table method with 61 patients in each group.The control group was treated with Shenmai injection,and the observation group was treated with alprostadil based on the treatment of the control group.The clinical effects,recovery time of clinical symptoms,serum biochemical indicators,and the incidence of adverse reactions were compared between the two groups.Results Compared with the control group,the total effective rate of treatment in the observation group was higher(90.16%vs 75.41%)(P<0.05),the recovery time of abdominal pain,bloating,nausea and vomiting and gastrointestinal function in the observation group was shorter(P<0.05).After treatment,the levels of amylase(AMY),lactate dehydrogenase(LDH),lipase(LPS)and creatinine(Cr)were decreased,and the levels of albumin(ALB)and prealbumin(PA)were increased in the two groups.Compared with the control group,the levels of AMY,LDH,LPS and Cr in the observation group were lower,and the levels of ALB and PA in the observation group were higher(P<0.05).After treatment,the levels of CRP,PCT and IL-6 in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group(9.84%)and the control group(8.20%)were nosignificantly difference(P>0.05).Conclusion Alprostadil can help strengthen the clinical efficacy of Shenmai injection in acute severe pancreatitis,improve the clinical symptoms and serum biochemical improvement effect,and has good safety and is worthy of clinical promotion.

关 键 词：急性重症胰腺炎 前列地尔 参麦注射液 C反应蛋白 降钙素原 

分 类 号：R576[医药卫生—消化系统]