结肠癌中西医动物模型研究进展  

Research progress on animal models of colon cancer in Traditional Chinese and Western Medicine

作　　者：申洋 王国娟[2] 朱柰澄 郭敏[1] 廖文静 余文燕[1] SHEN Yang;WANG Guojuan;ZHU Naicheng;GUO Min;LIAO Wenjing;YU Wenyan(Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine,Jiangxi University of Chinese Medicine,Key Laboratory of Etiology and Biology of Chinese Medicine in Jiangxi Province,Nanchang 330004,Jiangxi Province,China;Affiliated Hospital of Jiangxi University of Chinese Medicine(Jiangxi Provincial Hospital of Traditional Chinese Medicine),Nanchang 330006,Jiangxi Province,China)

机构地区：[1]江西中医药大学中医基础理论分化发展研究中心,江西省中医病因生物学重点实验室,江西南昌330004 [2]江西中医药大学附属医院(江西省中医院)肿瘤科,江西南昌330006

出　　处：《肿瘤》2024年第11期1116-1129,共14页Tumor

基　　金：国家自然科学基金项目(82205221,82160925);江西省自然科学基金面上项目(20224BAB206097,20242BAB25563);江西省卫健委科技计划项目(202211432)

摘　　要：结肠癌是消化系统中常见的恶性肿瘤,发病率和死亡率逐年上升。目前,结肠癌的病因尚未完全阐明,随着对结肠癌治疗研究的深入,建立相应的临床前体内模型显得尤为重要。在结肠癌治疗方面,中医遵循辨证论治的原则,采取扶正祛邪的方法,调整机体气血盛衰、脏腑功能的虚实以维持人体阴阳平衡从而达到抗肿瘤的目的。结肠癌的中医动物模型大致上可分为湿热蕴结、气滞血瘀、气血两虚、脾肾阳虚和肝肾阴虚等5类。结肠癌的西医动物模型常见的有自发型、诱导型、移植型和基因工程型等4类。本研究中总结了中西医当前常用结肠癌动物模型的构建方法与特点,基于如何选择动物模型、中西医造模方法比较及造模成功评价三方面,对结肠癌动物模型进行归纳、分析与总结,以期找寻合适的临床前实验的造模方法,从而为结肠癌动物模型选择提供指导。Colon cancer is a common malignant tumor in the gastrointestinal tract,with morbidity and mortality rates increasing every year.Currently,the etiology of colon cancer has not been fully elucidated.With the deepening of colon cancer research and treatment,it is especially important to establish corresponding preclinical in vivo models.In the treatment of colon cancer,Chinese medicine follows the principle of diagnosis and treatment,adopts the method of supporting the positive and dispelling the evil,adjusts the body's qi and blood,and the deficiency of internal organs to maintain the balance of the body's yin and yang,so as to achieve the purpose of anti-tumor.Chinese medicine animal models of colon cancer can be broadly divided into five categories:damp-heat accumulation,qi stagnation and blood stasis,qi and blood deficiency,spleen and kidney yang deficiency and liver and kidney yin deficiency.Western animal models of colon cancer are commonly divided into 4 categories:spontaneous,induced,transplanted and genetically engineered.The paper summarizes the construction methods and characteristics of colon cancer animal models currently commonly used in Chinese and western medicine,and summarizes,analyzes and concludes the colon cancer animal models based on three aspects:how to select animal models,comparison of Chinese and western medicine modeling methods and evaluation of modeling success,with a view to finding suitable modeling methods for preclinical experiments,so as to provide guidance for the selection of animal models of colon cancer.

关 键 词：结肠癌 中西医 动物模型 

分 类 号：R-332[医药卫生] R735.35