血清IL-6、Hcy、MLR及血脂水平与溃疡性结肠炎患者的相关性分析  

Correlation of serum interleukin-6 and homocysteine levels, monocyte-to-lymphocyte ratio, and serum lipid levels with ulcerative colitis

作　　者：祁智 庞健[2] 单慧明[3] 张皓 王腾祺[2] Qi Zhi;Pang Jian;Shan Huiming;Zhang Hao;Wang Tengqi(Department of Colorectal Surgery,Bayannur Hospital,Bayannur 015000,Inner Mongolia Autonomous Region,China;Department of Gastroenterology,Bayannur Hospital,Bayannur 015000,Inner Mongolia Autonomous Region,China;Department of Gastroenterology,Bayannur Hospital,Bayannur 015o0o,Inner Mongolia Autonomous Region,China)

机构地区：[1]巴彦淖尔市医院肛肠外科,巴彦淖尔015000 [2]巴彦淖尔市医院胃肠外科,巴彦淖尔015000 [3]巴彦淖尔市医院消化内科,巴彦淖尔015000

出　　处：《中国基层医药》2025年第2期239-244,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨血清白细胞介素6(IL-6)、同型半胱氨酸(Hcy)、巨噬细胞与淋巴细胞比值(MLR)及血脂水平[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]与溃疡性结肠炎的相关性。方法回顾性分析巴彦淖尔市医院2021年11月至2023年11月收治的溃疡性结肠炎患者98例(观察组)的临床资料, 并按2∶1比例选取同期体检健康者49例为对照组, 比较两组血清IL-6、Hcy、MLR及血脂水平的差异。通过受试者工作特征曲线(ROC曲线)分析血清IL-6、Hcy、MLR及血脂水平诊断溃疡性结肠炎的效能;通过Pearson相关性分析溃疡性结肠炎患者血清IL-6、Hcy、MLR及血脂水平的相关性。结果观察组IL-6、Hcy、MLR分别为(39.87±12.36)pg/mL、(13.01±3.52)μmol/L、(0.38±0.12), 均高于对照组的(22.3±3.26)pg/mL、(10.05±3.26)μmol/L、(0.29±0.08), TG、TC、LDL-C、HDL-C分别为(1.16±0.32)mmol/L、(4.12±1.15)mmol/L、(2.60±0.75)mmol/L、(1.02±0.17)mmol/L, 均低于对照组的(1.45±0.41)mmol/L、(4.91±0.99)mmol/L、(3.20±0.71)mmol/L、(1.13±0.16)mmol/L, 差异均有统计学意义(t=9.77、4.92、4.78、4.71、4.11、4.65、3.77, 均P < 0.05)。ROC曲线分析显示, 血清IL-6、Hcy、MLR、TG、TC、LDL-C、HDL-C水平诊断溃疡性结肠炎的曲线下面积(AUC)分别为0.957、0.749、0.746、0.732、0.678、0.722、0.681。Pearson相关性显示, 血清IL-6、Hcy、MLR、TG、TC、LDL-C、HDL-C水平水平均与溃疡性结肠炎患者严重程度存在相关(r=0.501、0.615、0.605、-0.577、-0.542、-0.548、-0.646, 均P < 0.05);溃疡性结肠炎患者血清IL-6、Hcy、MLR水平均与血脂水平呈负相关(r=-0.806、-0.801、-0.791、-0.649、-0.728、-0.671、-0.720、-0.655、-0.857、-0.877、-0.889、-0.583, 均P < 0.05)。结论溃疡性结肠炎患者血清IL-6、Hcy、MLR升高, 血脂水平降低, 且血清IL-6、Hcy、MLR及血脂水平与病情的严重程度有关, 血清IL-6、Hcy、MLR与血脂水平存在�Objective:To investigate the correlation of serum interleukin-6(IL-6)and homocysteine(Hcy)levels,monocyte-to-lymphocyte ratio(MLR),and serum lipid levels[triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)levels]with ulcerative colitis.Methods:The clinical data of 98 patients with ulcerative colitis admitted to Bayannur Hospital from November 2021 to November 2023(observation group)were retrospectively analyzed.Forty-nine healthy individuals who were selected at a 2:1 ratio during the same period were included in the control group.Serum IL-6 and Hcy levels,MLR,and lipid levels were compared between the two groups.The diagnostic efficacy of serum IL-6,Hcy,MLR,and lipid levels for ulcerative colitis was assessed using receiver operating characteristic(ROC)curves.Additionally,Pearson correlation analysis was conducted to analyze correlation of serum IL-6 and Hcy levels,MLR,and lipid levels with ulcerative colitis.Results:In the observation group,serum IL-6 and Hcy levels and MLR were(39.87±12.36)pg/mL,(13.01±3.52)μmol/L,and(0.38±0.12),respectively,all of which were significantly higher than those in the control group[(22.3±3.26)pg/mL,(10.05±3.26)μmol/L,(0.29±0.08),t=9.77,4.92,4.78,all P<0.05].In the observation group,serum levels of TG,TC,LDL-C,and HDL-C levels were(1.16±0.32)mmol/L,(4.12±1.15)mmol/L,(2.60±0.75)mmol/L,and(1.02±0.17)mmol/L,respectively,all of which were significantly lower than those in the control group[(1.45±0.41)mmol/L,(4.91±0.99)mmol/L,(3.20±0.71)mmol/L,(1.13±0.16)mmol/L,t=4.71,4.11,4.65,3.77,all P<0.05].ROC curve analysis indicated that the areas under the curve(AUC)for diagnosing ulcerative colitis based on serum levels of IL-6,Hcy,MLR,TG,TC,LDL-C,and HDL-C were 0.957,0.749,0.746,0.732,0.678,0.722,and 0.681,respectively.Pearson correlation analysis showed that serum levels of IL-6,Hcy,MLR,TG,TC,LDL-C,and HDL-C were all correlated with the severity of ulcerative colitis in patients(r=0.501,0.615,0.605,

关 键 词：结肠炎 溃疡性 白细胞介素6 半胱氨酸 巨噬细胞 淋巴细胞 血脂异常 

分 类 号：R574.62[医药卫生—消化系统]