囊腔型肺癌的临床诊疗研究进展  

Progress in clinical diagnosis and treatment of lung cancer associated with cystic airspaces

作　　者：成俊 郭春芬 吴坤 过江 康松涛 陈剑 Cheng Jun;Guo Chunfen;Wu Kun;Guo Jiang;Kang Songtao;Chen Jian(Department of Cardiothoracic Surgery,Xiangtan Central Hospital,Xiangtan 411100,China;Department of Pathology,Xiangtan Central Hospital,Xiangtan 411100,China)

机构地区：[1]湘潭市中心医院心胸外科,湘潭411100 [2]湘潭市中心医院病理科,湘潭411100

出　　处：《中华胸心血管外科杂志》2025年第2期115-120,共6页Chinese Journal of Thoracic and Cardiovascular Surgery

摘　　要：囊腔型肺癌(lung cancer associated with cystic airspaces,LCCA)属于比较少见的肺癌类型,具有特殊的形态学特点及影像学特征,但该病早期表现不典型,容易误诊,特别是薄壁光滑型LCCA。近年来有许多LCCA的相关研究,但主要集中在发病机制、影像学分类与诊断、病理分型与影像学形态表现的相关性等方面,有关该病的手术治疗方案的决策及后续管理方面的研究较少。此外,肺癌患者的术后的巩固治疗及内科治疗需结合TNM分期,特别是病理分期,但由于LCCA的特殊的形态,原发肿瘤的评价即T分期似乎不能较好地评估该肿瘤的预后。本文主要从LCCA的病因及发病机制,临床表现和影像学特征、形态学特点,诊断与鉴别诊断,病理和基因突变特点,治疗及预后等方面进行综述,为临床诊断和治疗LCCA提供参考。Lung cancer associated with cystic airspaces(LCCA)represents a less common subtype of lung cancer,possessing special morphological features and imaging characteristics.The disease often presents atypically in its early stages,frequently leading to misdiagnosis,especially in the variant with the feature of thin,smooth walls.Although there has been a significant body of research on LCCA in recent years,the focus has predominantly been on the pathogenesis,imaging classification and diagnosis,and the correlation between pathological types and imaging morphology.But,there is a limited number of research on surgical treatment strategies and subsequent management of this condition.Furthermore,postoperative consolidation and internal medical treatments for lung cancer patients necessitate integration with TNM staging,particularly the pathological stage.However,due to the unique morphology of LCCA,the primary tumor assessment(T staging)appears insufficient for accurately predicting the prognosis of the tumor.This article provides a comprehensive review of the etiology and pathogenesis of LCCA,its clinical presentation,imaging and morphological features,diagnosis and differential diagnosis,pathological and genetic mutation characteristics,treatment,and prognosis,thereby serving as a reference for the clinical diagnosis and treatment of LCCA.

关 键 词：巩固治疗 影像学特征 原发肿瘤 早期表现 治疗及预后 形态学特点 后续管理 基因突变 

分 类 号：R734.2[医药卫生—肿瘤]