牙齿漂白材料的研究新进展  

Recent progress in research on tooth bleaching materials

作　　者：苏晓凡 刘素汝 胡兴宇 刘磊[1,2] 田卫东[1,2] 谢利[1] Su Xiaofan;Liu Suru;Hu Xingyu;Liu Lei;Tian Weidong;Xie Li(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Engineering Research Center of Oral Translational Medicine,Ministry of Education&National Engineering Laboratory for Oral Regenerative Medicine,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、口腔转化医学教育部工程研究中心、口腔再生医学国家地方联合工程实验室,成都610041 [2]口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心、四川大学华西口腔医院创伤整形外科,成都610041

出　　处：《国际口腔医学杂志》2025年第2期176-182,共7页International Journal of Stomatology

基　　金：国家自然科学基金(32271415);国家重点研发计划(2022YFA1104400);四川省自然科学基金(2023NSFSC0561,2022-NSFSC1540);四川省科技支撑项目(2022YFS0283)。

摘　　要：目前临床应用的牙齿漂白材料主要以过氧化氢作为功能成分。为达到有效的漂白效果,通常需要使用高浓度过氧化氢或较长的接触时间。然而,高浓度过氧化氢或长接触时间常导致牙齿敏感、釉质损伤、软组织损伤等不良反应,这极大地限制了牙齿漂白材料的临床应用。近年来,以产生大量强氧化性自由基或者活性氧为特点的高级氧化技术飞速发展,为研发新型牙齿漂白材料提供了新策略和新方法,可望提高牙齿漂白的治疗效果并减少或避免其并发症。本文系统性地总结了牙齿漂白材料的研究新进展,着重介绍其种类、作用机制、有效性和安全性评价结果。同时,也对研究中存在的不足以及未来发展方向进行了评述。Hydrogen peroxide is the primary functional component in tooth bleaching materials in clinical applications.Achieving effective bleaching outcomes typically necessitates the use of high concentrations of hydrogen peroxide or prolonged contact times.However,the application of high concentrations or prolonged contact times often results in adverse effects,such as tooth sensitivity,enamel damage,and soft tissue irritation,significantly constraining the clinical utility of tooth bleaching materials.In recent years,advanced oxidation processes have rapidly developed and are characterized by the generation of numerous strong oxidative free radicals or reactive oxygen species.This advancement provides new strategies and methods for the formulation of innovative tooth bleaching mate-rials to improve therapeutic effects while minimizing or avoiding associated complications.This article systematically reviews the research progress of novel tooth bleaching materials and presents results from assessments of material effectiveness and safety.Additionally,the article addresses existing research limitations and provides insights into potential directions for future studies.

关 键 词：牙齿漂白材料 高级氧化技术 类芬顿反应 光催化 压电催化 

分 类 号：R781[医药卫生—口腔医学]