牙髓根尖周病与糖尿病相互关系及相关机制的研究进展  

Progress in research on the correlation of inflammatory pulpal and periapical disease to diabetes mellitus and related mechanisms

作　　者：董馨璐 许来俊 张剑英[1] 陈敏慜[1] Dong Xinlu;Xu Laijun;Zhang Jianying;Chen Minmin(Xiangya School of Stomatology,Central South University&Dept.of Endodontics,Hunan Xiangya Stomatological Hospital&Hunan Key Laboratory of Oral Health Research&Hunan Clinical Research Center of Oral Major Diseases and Oral Health,Changsha 410008,China)

机构地区：[1]中南大学湘雅口腔医学院、湖南中南大学湘雅口腔医院牙体牙髓病科、口腔健康研究湖南省重点实验室、湖南省口腔重大疾病与口腔健康临床医学研究中心,长沙410008

出　　处：《国际口腔医学杂志》2025年第2期231-237,共7页International Journal of Stomatology

基　　金：湖南省自然科学基金(2022JJ40733);湖南省卫生健康委员会科研计划项目(202208015033);长沙市自然科学基金(kq2208180)。

摘　　要：牙髓根尖周病是常见的口腔感染性疾病,可影响口颌系统的健康。近年来,有越来越多的研究报道牙髓根尖周病和糖尿病的关系,但二者相互影响的潜在机制仍未阐明。本文通过回顾近期文献,主要从糖尿病胰岛素抵抗、微生物免疫炎症反应、成骨与破骨的失衡和氧化应激等方面总结牙髓根尖周病与糖尿病的相关性和相互作用的可能机制,以期为糖尿病患者的牙髓根尖周病治疗提供理论基础和指导依据。Dental pulp and periapical diseases are prevalent infectious oral conditions that can affect the well-being of the stomatognathic system.In recent years,a growing number of studies have highlighted the correlations of pulp and periapical diseases to diabetes,but the mechanism underlying this correlation remains unclear.This review aims to present a comprehensive summary of the possible mechanisms,including insulin resistance,microbial immune inflammatory response,imbalance between osteogenesis and osteolysis,and oxidative stress.Ultimately,this review seeks to offer a theoretical framework and clinical guidance for the management of dental pulp and periapical diseases in individuals with diabetes mellitus.

关 键 词：牙髓病 根尖周病 糖尿病 微生物 免疫 

分 类 号：R781.3[医药卫生—口腔医学]