唾液腺微分泌性腺癌临床病理的研究进展  

Clinical pathological study on the microsecretory adenocarcinoma of salivary glands

作　　者：揭伟萍 胡济安[1] 李怡宁[1] Jie Weiping;Hu Ji’an;Li Yining(Dept.of Pathology,Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属口腔医院病理科、浙江大学口腔医学院、浙江省口腔疾病临床医学研究中心、浙江省口腔生物医学研究重点实验室、浙江大学癌症研究院、口腔生物材料与器械浙江省工程研究中心,杭州310000

出　　处：《国际口腔医学杂志》2025年第2期257-262,共6页International Journal of Stomatology

基　　金：浙江省医药卫生科技计划项目(2022516638,2017KY448);浙江省教育厅一般科研项目(Y202147707)。

摘　　要：微分泌性腺癌(MSA)是第5版世界卫生组织(WHO)头颈肿瘤分类中新增的一类唾液腺上皮源性低度恶性肿瘤。MSA有独特的组织学形态、免疫组织化学表型及分子遗传改变。组织学上,MSA可排列呈微囊型、筛状、小管样和条索样,囊腔或管腔内含丰富的嗜碱性分泌物,肿瘤由闰管样细胞组成,细胞形态单一,肿瘤间质为纤维黏液样组织。免疫组织化学表型上,MSA肿瘤细胞常表现为SOX10、S100、p63阳性,p40、calponin和mammaglobin阴性;平滑肌肌动蛋白可表现为阳性或阴性。MSA表现为特异性MEF2C∶∶SS18基因融合。MSA需与分泌性癌、硬化性微囊性腺癌、多形性腺癌、腺样囊性癌、分泌性肌上皮癌等进行鉴别。Microsecretory adenocarcinoma(MSA)is a new entity in the 5th edition of the Word Health Organization(WHO)Classification of Head and Neck Tumors.It is a low-grade malignant epithelial tumor of the salivary gland and has unique histological characteristics,immunoprofile,and molecular features.Histologically,MSA shows many growth patterns,including microcystic,cribriform,tubular,and cords,with abundant basophilic secretions in the lumens.The tumor is composed of a single population of intercalated duct-like cells.The stroma is fibromyxoid.For its immunoprofile,MSA is positive for SOX10,S100,and p63 and negative for p40,calponin,and mammaglobin.Meanwhile,MSA is va-riable for smooth muscle actin and exhibits a specific MEF2C∶∶SS18 gene fusion.The differential diagnosis for MSA includes secretory carcinoma,sclerosing microcystic adenocarcinoma,polymorphic adenocarcinoma,adenoid cystic carcinoma,and secretory myoepithelial carcinoma.

关 键 词：微分泌性腺癌 唾液腺肿瘤 MEF2C∶∶SS18基因融合 

分 类 号：R739.87[医药卫生—肿瘤]