青少年抑郁症自伤自杀行为与非酶类抗氧化物及甲状腺激素水平分析  

Study on self-injurious and suicidal behavior,non-enzymatic antioxidants and thyroid hormones in adolescents with depressive disorder

作　　者：王学斐 陈曼曼 滕玉欣 曾波涛[2] WANG Xuefei;CHEN Manman;TENG Yuxin;ZENG Botao(College of Mental Health,Jining Medical University,Jining 272067,Shandong,China;Department of Psychology Ⅱ,Qingdao Mental Health Center,Qingdao 266034,Shandong,China;Qingdao University Medical College,Qingdao 266071,Shandong,China)

机构地区：[1]济宁医学院精神卫生学院,山东济宁272067 [2]青岛市精神卫生中心心理二科,山东青岛266034 [3]青岛大学医学部,山东青岛266071

出　　处：《中国现代医生》2025年第5期15-18,共4页China Modern Doctor

摘　　要：目的分析青少年抑郁症患者的自伤、自杀行为与非酶类抗氧化物水平、甲状腺激素水平的关系。方法选取2023年8月至2024年5月于青岛市精神卫生中心住院的93例青少年抑郁症患者为研究对象,分为抑郁症伴自伤行为组(自伤组,n=30)、抑郁症伴自杀行为组(自杀组,n=30)及抑郁症不伴自伤自杀行为组(抑郁组,n=33)。检测患者入院时及治疗8周后血浆非酶类抗氧化物及甲状腺激素水平,采用汉密尔顿抑郁量表、汉密尔顿焦虑量表评定患者临床症状。比较三组患者的血浆非酶类抗氧化物水平、甲状腺功能及量表评分差异。结果与抑郁组比较,自伤组和自杀组患者的基线尿酸水平更低(P<0.05)。治疗8周后自伤组患者的游离三碘甲状腺原氨酸水平高于自杀组(P<0.05),三组患者的汉密尔顿抑郁量表、汉密尔顿焦虑量表评分均下降,校正后自杀组患者的汉密尔顿焦虑量表评分高于抑郁组(P<0.05)。三组患者治疗后的促甲状腺激素水平均升高,汉密尔顿抑郁量表及汉密尔顿焦虑量表评分均下降(P<0.05),自杀组患者治疗后的总胆红素、游离三碘甲状腺原氨酸水平下降,尿酸水平增加,抑郁组患者治疗后的游离甲状腺素水平下降(P<0.05)。结论非酶类抗氧化物可作为青少年抑郁症患者自伤、自杀行为的潜在生物学指标。Objective To investigate the correlation between self-injurious and suicidal behavior in adolescents with depressive disorder and their non-enzymatic antioxidants and thyroid hormones.Methods A total of 93 adolescent patients with depressive disorder who were hospitalized at the Qingdao Mental Health Center from August 2023 to May 2024 were selected as the research subjects.The patients were divided into three groups:depression group(n=33),self-injurious behavior group(n=30)and a suicidal behavior.Plasma levels of non-enzymatic antioxidants and thyroid hormones were measured at admission and after 8 weeks of treatment,and their clinical symptoms were assessed by the Hamilton depression scale(HAMD)and the Hamilton anxiety scale(HAMA).Differences in plasma non-enzymatic antioxidants and thyroid function levels and scale scores were compared among three groups.Results Compared with depression group,baseline UA levels were lower in self-injurious and suicidal behavior groups.After 8 weeks of treatment,FT3 levels were higher in self-injurious group than in the suicidal behavior group,and both HAMD and HAMA scores decreased in all patients.After correction,HAMA scores were higher in suicidal behavior group than in depression group(P=0.047).Compared to baseline levels,TSH levels increased,and HAMD and HAMA scores decreased in all groups after treatment(P<0.001).In suicidal behavior group,TBIL and FT3 levels decreased,and UA levels increased after treatment,while in depression group,FT4 levels decreased after treatment.Conclusion Non-enzymatic antioxidants may serve as potential biological markers for adolescents with depressive disorder who exhibit self-injurious and suicidal behavior.

关 键 词：自杀行为 自伤行为 非酶类抗氧化物 甲状腺激素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]