脑电图结合miR-146a-5p预测阿尔茨海默病患者认知功能障碍研究  

Electroencephalograph combined with miR-146a-5p to predict cognitive dysfunction in Alzheimer’s disease patients

作　　者：陈佳琦 向红英 凌迎春 CHEN Jiaqi;XIANG Hongying;LING Yingchun(Department of Special Inspection,Shaoxing Seventh People’s Hospital,Shaoxing 312000,Zhejiang,China)

机构地区：[1]绍兴市第七人民医院特检科,浙江绍兴312000

出　　处：《中国现代医生》2025年第5期23-26,56,共5页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2022KY1309)。

摘　　要：目的探讨脑电图定量参数结合血清微小核糖核酸(microRNA,miR)-146a-5p对阿尔茨海默病(Alzheimer’s disease,AD)患者认知功能障碍的预测价值。方法选取绍兴市第七人民医院2022年3月至2024年5月确诊的96例AD患者,根据蒙特利尔认知量表(Montreal cognitive assessment,MoCA)评分评估患者是否存在认知功能障碍,40例存在认知功能障碍的患者为发生组(MoCA评分<26分),56例认知功能正常的患者为未发生组(MoCA评分≥26分),比较两组患者的脑电图定量参数、血清miR-146a-5p,采用Logistic回归分析AD患者发生认知功能障碍的危险因素,采用受试者操作特征曲线分析脑电图定量参数、血清miR-146a-5p对AD患者发生认知功能障碍的预测效能。结果发生组患者的δ频段、θ频段、血清miR-146a-5p均较未发生组更低,发生组患者的β频段、α频段均较未发生组更高(P<0.05)。δ频段、θ频段、miR-146a-5p、年龄、受教育年限是AD患者发生认知功能障碍的危险因素(P<0.05)。δ频段、θ频段、β频段、α频段、miR-146a-5p联合预测AD患者发生认知功能障碍的曲线下面积为0.908,δ频段、θ频段、β频段、α频段、miR-146a-5p联合预测AD患者发生认知功能障碍的敏感度较单独检测更高(P<0.05)。结论δ频段、θ频段、血清miR-146a-5p降低、β频段、α频增高与AD患者发生认知功能障碍联系密切,联合检测脑电图定量参数、血清miR-146a-5p,可提高对认知功能障碍的预测效能。Objective To explore the predictive value of electroencephalograph(EEG)quantitative parameters combined with serum microRNAs(miR)-146a-5p in cognitive dysfunction in patients with Alzheimer’s disease(AD).Methods A total of 96 AD patients diagnosed in Shaoxing Seventh People’s Hospital from March 2022 to May 2024 were selected to assess whether the patients had cognitive impairment according to the Montreal cognitive scale(MoCA)score,and 40 patients with cognitive impairment were set as occurrence group(MoCA score<26points).A total of 56 patients with normal cognitive function were set as non-developing group(MoCA score≥26points).Quantitative electroencephalography(EEG)parameters and serum miR-146a-5p were compared between the two groups.The risk factors of cognitive dysfunction in AD patients were analyzed by Logistic regression,and receiver operating characteristic curve was used to predict efficacy of EEG quantitative parameters and serum miR-146a-5p on cognitive dysfunction in AD patients.Results The δ frequency band,θ frequency band,and serum miR-146a-5p levels were lower in occurrence group than those in non occurrence group,while β frequency band and α frequency band were higher in occurrence group than in those non occurrence group(P<0.05).δ frequency band,θ frequency band,miR-146a-5p,age,and years of education were risk factors for cognitive dysfunction in AD patients(P<0.05).The area under the curve(AUC)of predicting cognitive impairment in AD patients using the combination of δ frequency band,θ frequency band,β frequency band,α frequency band,and miR-146a-5p was 0.908.The sensitivity of predicting cognitive impairment in AD patients using the combination of delta frequency band,δ frequency band,βfrequency band,α frequency band,and miR-146a-5p was higher than that of individual detection(P<0.05).Conclusion The decrease in δ frequency band,θ frequency band,serum miR-146a-5p,and the increase in β frequency band and α frequency are closely related to the occurrence of cognitive dysfun

关 键 词：脑电图 微小核糖核酸-146a-5p 阿尔茨海默病 认知功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]