糖尿病视网膜病变患者血清信号肽Cub-Egf结构域蛋白1、微小RNA-141-3p、骨膜蛋白与眼底病变的相关性  

Correlation of serum signal peptide Cub-Egf domain protein 1,micro RNA-141-3p,periosteum protein and fundus lesions in diabetic retinopathy patients

作　　者：刘玮 傅佳琪 毛蕾 LIU Wei;FU Jiaqi;MAO Lei(Department of Ophthalmology,Xinyu People's Hospital,Jiangxi Province,Xinyu 338000,China)

机构地区：[1]江西省新余市人民医院眼科,江西新余338000

出　　处：《中国当代医药》2025年第4期23-26,35,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202311794)。

摘　　要：目的探讨糖尿病视网膜病变(DR)患者血清信号肽Cub-Egf结构域蛋白1(SCUBE-1)、微小RNA-141-3p(miR-141-3p)、骨膜蛋白(POSTN)与眼底病变的相关性。方法选取2021年4月至2023年4月新余市人民医院收治的147例糖尿病患者,根据是否并发DR分为DR组(n=103)及无DR组(n=44)。比较两组血清SCUBE-1、miR-141-3p、POSTN水平;按照DR病变分期将DR患者分为非增生型DR(n=60)和增生型DR(n=43),比较两者血清SCUBE-1、miR-141-3p、POSTN水平;采用Pearson相关性分析血清SCUBE-1、miR-141-3p、POSTN水平和眼底病变的相关性;通过多因素logistic回归分析SCUBE-1、miR-141-3p、POSTN对糖尿病患者DR严重程度的影响。结果DR组SCUBE-1、POSTN水平高于无DR组,miR-141-3p低于无DR组,差异有统计学意义(P<0.05);增生型DR组患者血清POSTN、SCUBE-1高于非增生型DR组,miR-141-3p低于非增生型DR组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,miR-141-3p与DR程度呈负相关,SCUBE-1、POSTN与DR程度呈正相关(P<0.05);多因素logistic回归分析显示,血清SCUBE-1、POSTN均是影响DR严重程度的危险因素,而miR-141-3p为保护因素(P<0.05)。结论SCUBE-1、miR-141-3p、POSTN与DR发生及眼底病变程度密切相关,监测三者变化情况可指导临床治疗、评估疗效及预测眼底病变发生。Objective To investigate the correlation between signal peptide Cub-Egf like domain containing protein(SCUBE-1),microRNA-141-3p(miR-141-3p),periostin(POSTN)and fundus lesions in patients with diabetic retinopathy(DR).Methods A total of 147 diabetic patients admitted to Xinyu People's Hospital from April 2021 to April 2023 were selected and divided into DR group(n=103)and no DR group(n=44)according to whether they had concurrent DR.Serum levels of SCUBE-1,miR-141-3p and POSTN were compared between the two groups.The patients with DR were divided into non-proliferative type DR(n=60)and proliferative type DR(n=43)according to the pathological stages of DR,and the serum levels of SCUBE-1,miR-141-3p and POSTN were compared.Pearson correlation was used to analyze the correlation between serum SCUBE-1,miR-141-3p,POSTN levels and fundus lesions.The effects of SCUBE-1,miR-141-3p and POSTN on the severity of DR In diabetic patients were analyzed by multivariate logistic regression.Results The SCUBE-1 and POSTN levels in DR Group were higher than those in no-DR group,and miR-141-3p was lower than that in no-DR group,with statistical significances(P<0.05).The serum POSTN and SCUBE-1 in proliferative DR group were higher than those in non-proliferative DR group,and miR-141-3p were lower than those in non-proliferative DR group,with statistical significances(P<0.05).Pearson correlation analysis showed that miR-141-3p was negatively correlated with DR degree,while SCUBE-1 and POSTN were positively correlated with DR degree(P<0.05).Multivariate logistic regression analysis showed that serum SCUBE-1 and POSTN were both risk factors affecting the severity of DR,while miR-141-3p was a protective factor(P<0.05).Conclusion SCUBE-1,miR-141-3p and POSTN are closely related to the occurrence of DR and the degree of fundus lesions.Monitoring the changes of the three factors can guide clinical treatment,evaluate efficacy and predict the occurrence of fundus lesions.

关 键 词：糖尿病视网膜病变 信号肽Cub-Egf结构域蛋白1 微小RNA-141-3p 骨膜蛋白 眼底病变 

分 类 号：R774[医药卫生—眼科]