银杏内酯联合高压氧对脑梗死恢复期的治疗效果  

Therapeutic effect of Ginkgolide combined with hyperbaric oxygen on cerebral infarction recovery period

作　　者：樊赛君 胡莹 付瑶 张传林 俞琪 FAN Saijun;HU Ying;FU Yao;ZHANG Chuanlin;YU Qi(Department of Nephrology,Shangrao Central Hospital,the First Affiliated Hospital of Jiangxi Medical College,Jiangxi Province,Shangrao 334000,China;Department of Clinical Laboratory,Shangrao Central Hospital,the First Affiliated Hospital of Jiangxi Medical College,Jiangxi Province,Shangrao 334000,China;Department of Pharmacy,Shangrao Central Hospital,the First Affiliated Hospital of Jiangxi Medical College,Jiangxi Province,Shangrao 334000,China)

机构地区：[1]江西省上饶市中心医院,江西医学高等专科学校第一附属医院肾内科,江西上饶334000 [2]江西省上饶市中心医院,江西医学高等专科学校第一附属医院检验科,江西上饶334000 [3]江西省上饶市中心医院,江西医学高等专科学校第一附属医院药学部,江西上饶334000 [4]江西省上饶市中心医院,江西医学高等专科学校第一附属医院药剂科,江西上饶334000

出　　处：《中国当代医药》2025年第4期56-59,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202410971)。

摘　　要：目的探讨银杏内酯联合高压氧治疗脑梗死恢复期的临床效果。方法选取2022年1月至2023年9月上饶市中心医院收治的82例脑梗死患者作为研究对象,按随机数表法分为对照组(41例)和观察组(41例)。对照组采用常规治疗,观察组基于对照组采用银杏内酯联合高压氧治疗,比较两组的治疗效果、血脂水平、神经功能、日常生活能力及不良反应,并分析成本-效果情况。结果观察组的总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗10 d后的甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平、美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,高密度脂蛋白胆固醇(HDL-C)水平、日常生活能力量表(ADL)评分高于对照组,差异有统计学意义(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05);经成本-效果分析法分析,观察组成本(C)/效果(E)低于对照组。结论银杏内酯联合高压氧治疗脑梗死恢复期患者效果较好,可降低血脂水平,改善神经功能与日常生活能力,且不良反应少、治疗成本低,占据经济优势。Objective To explore the clinical effect of Ginkgolides combined with hyperbaric oxygen in the treatment of cerebral infarction recovery.Methods A total of 82 patients with cerebral infarction admitted to Shangrao Central Hospital from January 2022 to September 2023 were selected as the research objects,and they were divided into control group(41 cases)and observation group(41 cases)according to random number table method.The control group was treated with conventional treatment,and the observation group was treated with Ginkgolides combined with hyperbaric oxygen based on the control group.The therapeutic effect,blood lipid level,neurological function,daily living ability and adverse reactions were compared between the two groups,and the cost-effectiveness was analyzed.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After 10 days of treatment,the levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and National Institutes of Health stroke Scale(NIHSS)scores in the observation group were lower than those in the control group,and the levels of high-density lipoprotein cholesterol(HDL-C)and activities of daily living(ADL)scores were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The cost-effectiveness analysis showed that the cost(C)/effect(E)of the observation group was lower than that of the control group.Conclusion Ginkgolides combined with hyperbaric oxygen is effective in the treatment of patients with cerebral infarction in convalescent stage.It can reduce blood lipid levels,improve neurological function and daily living ability,and has fewer adverse reactions,low treatment cost and economic advantages.

关 键 词：脑梗死 恢复期 银杏内酯 高压氧 神经功能 

分 类 号：R743[医药卫生—神经病学与精神病学]