补肾固齿丸联合多西环素治疗糖尿病性牙周炎的效果  

Effect of Bushen Guchi Pills combined with Doxycycline in the treatment of diabetes periodontitis

作　　者：李丽惠 林结仪 曾金妹 刘静敏 LI Lihui;LIN Jieyi;ZENG Jinmei;LIU Jingmin(Department of Stomatology,Guangzhou Dongsheng Hospital,Guangdong Province,Guangzhou 510663,China;Department of Clinical Laboratory,Guangzhou Dongsheng Hospital,Guangdong Province,Guangzhou 510663,China)

机构地区：[1]广东省广州市东升医院口腔科,广东广州510663 [2]广东省广州市东升医院检验科,广东广州510663

出　　处：《中国当代医药》2025年第4期93-96,共4页China Modern Medicine

基　　金：广东省广州民政科技基金项目(2021MZK14)。

摘　　要：目的探讨补肾固齿丸联合多西环素治疗糖尿病性牙周炎的效果。方法选取2024年1月至3月广州市东升医院口腔科收治的62例糖尿病合并牙周炎患者作为研究对象,按照随机数字表法分为观察组与对照组,每组31例。对照组接受多西环素治疗,观察组接受补肾固齿丸联合多西环素治疗。比较两组患者的牙周指数、综合疗效以及不良反应发生情况。结果两组患者治疗后的牙周探诊深度(PD)、附着水平(AL)、牙齿松动度(TM)低于本组治疗前,差异有统计学意义(P<0.05)。观察组治疗后的PD、AL、TM水平低于对照组,差异有统计学意义(P<0.05)。观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论糖尿病性牙周炎患者联合应用补肾固齿丸与多西环素,能够有效改善患者PD、AL、TM等牙周指数,提升治疗效果,且不会增加不良反应的发生风险,具有较好的安全性和临床价值。Objective To investigate the effect of Bushen Gushi Pills combined with Doxycycline on diabetic periodontitis.Methods A total of 62 patients with diabetes mellitus combined with periodontitis admitted to the Department of Stomatology of Guangzhou Dongsheng Hospital from January to March 2024 were selected as the research objects,and they were divided into observation group and control group according to random number table method,with 31 cases in each group.The control group received Doxycycline,and the observation group received bushen Gushi Pills combined Doxycycline treatment.Periodontal index,comprehensive efficacy and adverse reactions were compared between the two groups.Results The pocket depth(PD),attachment level(AL)and tooth mobility(TM)after treatment were lower than those before treatment in the two groups,and the differences were statistically significant(P<0.05).The levels of PD,AL and TM in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Bushen Gushi Pills and Doxycycline can effectively improve PD,AL,TM and other periodontal indexes of patients with diabetic periodontitis,improve the therapeutic effect,does not increase the risk of adverse reactions,and has good safety and clinical value.

关 键 词：糖尿病 牙周炎 牙周指数 安全性 中成药 

分 类 号：R781.42[医药卫生—口腔医学]