神经介入联合静脉溶栓治疗急性脑梗死的效果分析  

Effect analysis of neurointervention combined with intravenous thrombolysis in the treatment of acute cerebral infarction

作　　者：叶育霜 YE Yu-shuang(Department of Neurology,Quanzhou First Hospital,Quanzhou 362000,China)

机构地区：[1]泉州市第一医院神经内科,362000

出　　处：《中国现代药物应用》2025年第4期42-44,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析神经介入联合静脉溶栓对急性脑梗死患者的治疗效果。方法选取90例急性脑梗死患者,按照其接受治疗措施的差异分为联合组(50例,接受神经介入联合静脉溶栓治疗)与对照组(40例,接受静脉溶栓治疗)。比较两组治疗效果、血流分级情况、神经功能恢复情况、治疗随访中不良事件发生情况。结果联合组治疗总有效率98.00%(49/50)高于对照组的87.50%(35/40)(P<0.05)。联合组治疗后1个月心肌梗死溶栓(TIMI)血流分级0、1级占比显著低于对照组,3级占比显著高于对照组(P<0.05)。治疗后1个月,联合组美国国立卫生研究院卒中量表(NIHSS)评分(5.01±1.63)分、改良Rankin量表(mRS)评分(2.01±0.65)分均低于对照组的(6.98±1.44)、(2.56±0.81)分(P<0.05)。联合组治疗后48 h颅内出血率4.00%(2/50)、随访3个月死亡率4.00%(2/50)与对照组的2.50%(1/40)、5.00%(2/40)比较,差异无显著性(P>0.05)。结论对急性脑梗死患者开展神经介入联合静脉溶栓治疗临床效果较高,有助于改善患者血流分级和神经缺损情况,且不良事件发生率未出现明显变化。Objective To analyze the therapeutic effect of neurointervention combined with intravenous thrombolysis in the treatment of patients with acute cerebral infarction.Methods 90 patients with acute cerebral infarction were selected as the research subjects.According to the difference in treatment measures,the patients were divided into combined group(50 cases,neurointervention combined with intravenous thrombolysis)and control group(40 cases,intravenous thrombolysis).The therapeutic effect,blood flow classification neurological function recovery,and the occurrence of adverse events during treatment follow-up were compared between the two groups.Results The total effective rate of the combined group was 98.00%(49/50),which was higher than 87.50%(35/40)of the control group(P<0.05).1 month after treatment,the thrombolysis in myocardial infarction(TIMI)grade 0 and 1 blood flow in the combined group was significantly lower than that in the control group,and the proportion of grade 3 blood flow was significantly higher than that in the control group(P<0.05).1 month after treatment,the National Institutes of Health Stroke Scale(NIHSS)score and modified Rankin Scale(mRS)score were(5.01±1.63)and(2.01±0.65)points in the combined group,which were lower than(6.98±1.44)and(2.56±0.81)points in the control group(P<0.05).In the combined group,the rate of intracranial hemorrhage at 48 h of treatment was 4.00%(2/50)and the death rate at 3 months of follow-up was 4.00%(2/50),and those in the control group were 2.50%(1/40)and 5.00%(2/40);there was no significant difference in comparison(P>0.05).Conclusion The combination of neurointervention and intravenous thrombolysis has a high clinical effect in patients with acute cerebral infarction,which is helpful to improve the classification of blood flow and neurological defect of patients,and there is no significant change in the incidence of adverse events.

关 键 词：神经介入 静脉溶栓 急性脑梗死 临床效果 神经缺损 颅内出血 安全性 血流分级 

分 类 号：R743.33[医药卫生—神经病学与精神病学]