数字减影下经皮穿刺胃造瘘术行胃肠内营养治疗食管贲门癌性狭窄的疗效  

The efficacy of percutaneous gastrostomy under digital subtraction angiography for enteral nutrition treatment of esophageal and cardia cancerous stenosis

作　　者：张春生[1] 彭建扬[1] 翁志成[1] ZHANG Chun-sheng;PENG Jian-yang;WENG Zhi-cheng(Department of Interventional and Vascular Surgery,Affiliated Hospital of Putian University,Putian 351100,China)

机构地区：[1]莆田学院附属医院介入与血管外科,351100

出　　处：《中国现代药物应用》2025年第4期48-51,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨数字减影下经皮穿刺胃造瘘术行胃肠内营养治疗食管贲门癌性狭窄的疗效。方法选取50例食管癌、喉癌等食管贲门癌性狭窄患者,将采用肠外营养支持的25例患者作对照组,将采用数字减影下完成经皮穿刺胃造瘘术行胃肠内营养治疗的25例患者作观察组。对比两组患者营养指标[血清白蛋白(ALB)、血清总蛋白(TP)、血浆血红蛋白(Hb)]、机体免疫细胞、生存质量、不良事件发生情况。结果治疗后,观察组ALB、TP、Hb分别为(35.05±4.05)、(66.83±9.48)、(101.26±10.52)g/L,高于对照组的(32.20±3.26)、(60.50±8.73)、(94.72±9.91)g/L(P<0.05)。治疗后,观察组CD4+(38.29±6.16)%高于对照组的(34.10±4.37)%,CD8+(24.83±3.92)%低于对照组的(26.78±3.17)%(P<0.05)。治疗后,观察组世界卫生组织生存质量测定简表(WHOQOL-BREF)评分为(86.52±14.29)分,高于对照组的(70.71±15.36)分(P<0.05)。治疗期间,观察组不良事件发生率为16.00%,低于对照组的52.00%(P<0.05)。结论数字减影下经皮穿刺胃造瘘术行肠内营养支持治疗是一种理想的营养支持方式,能够满足食管贲门癌性狭窄患者的营养摄入需求,改善患者营养指标,并降低不良事件发生风险,使患者的免疫功能得到调节,获得更理想的生存质量。Objective To explore the efficacy of percutaneous gastrostomy under digital subtraction angiography for enteral nutrition treatment of esophageal and cardia cancerous stenosis.Methods 50 patients with esophageal cancer,laryngeal cancer and other esophageal and cardia cancerous stenosis were selected,and 25 patients with parenteral nutrition support were taken as the control group,and 25 patients with gastrointestinal enteral nutrition treatment after percutaneous gastrostomy under digital subtraction angiography were taken as the observation group.The nutritional indexes[serum albumin(ALB),serum total protein(TP),plasma hemoglobin(Hb)],immune cells,quality of life,and incidence of adverse events were compared between two groups of patients.Results After treatment,ALB,TP and Hb in the observation group were(35.05±4.05),(66.83±9.48)and(101.26±10.52)g/L,which were higher than(32.20±3.26),(60.50±8.73)and(94.72±9.91)g/L in the control group(P<0.05).After treatment,the observation group had a higher CD4^(+)of(38.29±6.16)%than(34.10±4.37)%in the control group,and a lower CD8^(+)of(24.83±3.92)%than(26.78±3.17)%in the control group(P<0.05).After treatment,the observation group had a higher World Health Organization Quality of Life Scale Brief Version(WHOQOL-BREF)score of(86.52±14.29)points than(70.71±15.36)points of the control group(P<0.05).During the treatment period,the incidence of adverse events in the observation group was 16.00%,which was lower than 52.00%in the control group(P<0.05).Conclusion Enteral nutritional support by percutaneous gastrostomy under digital subtraction angiography is an ideal nutrition support method,which can meet the nutrition intake requirements of patients with esophageal and cardia cancerous stenosis,improve the nutritional indexes of patients,and reduce the risk of adverse events,so as to regulate the immune function of the patients and obtain a better quality of life.

关 键 词：食管癌 喉癌 数字减影 经皮穿刺胃造瘘术 肠内营养支持 

分 类 号：R73[医药卫生—肿瘤]