分析腹腔镜微创手术对结直肠癌患者疼痛、胃肠道功能的影响  

Analysis of the impact of minimally invasive laparoscopic surgery on pain and gastrointestinal function in patients with colorectal cancer

作　　者：侯俊光[1] 沈颜芹[1] HOU Jun-guang;SHEN Yan-qin(Linqu County People's Hospital,Weifang 262600,China)

机构地区：[1]临朐县人民医院,262600

出　　处：《中国现代药物应用》2025年第4期52-55,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析腹腔镜微创手术对结直肠癌患者疼痛、胃肠道功能的影响。方法92例结直肠癌患者为研究对象,按治疗方式的不同分为对照组和观察组,每组46例。对照组行传统开腹手术,观察组行腹腔镜微创手术。比较两组手术前后疼痛介质水平、能量代谢指标、氧化应激指标、胃肠道功能指标及生活质量。结果两组术后3 d前列腺素E_(2)、神经生长因子、神经肽Y水平均较术前升高,但前列腺素E_(2)(162.05±13.25)ng/L、神经生长因子(262.21±20.82)ng/L、神经肽Y(139.65±12.15)ng/L均较对照组的(181.82±16.72)、(271.16±21.96)、(160.91±15.20)ng/L更低(P<0.05)。两组术后3 d转铁蛋白、视黄醇结合蛋白、前白蛋白均较术前降低,但观察组转铁蛋白(2.97±0.34)g/L、视黄醇结合蛋白(19.27±1.39)mg/L、前白蛋白(252.95±16.38)mg/L均较对照组的(2.10±0.25)g/L、(17.19±1.02)mg/L、(221.03±13.78)mg/L更高(P<0.05)。两组术后3 d血清丙二醛、氧化型谷胱甘肽均较术前降低,超氧化物歧化酶、还原型谷胱甘肽均较术前升高,且观察组血清丙二醛、氧化型谷胱甘肽均较对照组更低,超氧化物歧化酶、还原型谷胱甘肽均较对照组更高(P<0.05)。两组术后3 d胃动素、胃泌素水平较均术前升高,且观察组各指标水平均较对照组更高(P<0.05)。两组术后60 d躯体功能、社会功能、情绪功能、角色功能、认知功能评分均较术前升高,且观察组各指标评分均较对照组更高(P<0.05)。结论腹腔镜微创手术在结直肠癌患者中应用效果良好,值得推广。Objective To analyze the impact of minimally invasive laparoscopic surgery on pain and gastrointestinal function in patients with colorectal cancer.Methods 92 patients with colorectal cancer were divided into control group and observation group according to different treatment methods,with 46 cases in each group.The control group underwent traditional open surgery,and the observation group underwent minimally invasive laparoscopic surgery.The pain mediator levels,energy metabolism indexes,oxidative stress indexes,gastrointestinal function index and quality of life before and after surgery were compared between the two groups.Results At 3 d after surgery,the levels of prostaglandin E_(2),nerve growth factor and neuropeptide Y in both groups were increased compared with before surgery;in the observation group,the prostaglandin E_(2) was(162.05±13.25)ng/L,the nerve growth factor was(262.21±20.82)ng/L,and the neuropeptide Y was(139.65±12.15)ng/L,which were lower than(181.82±16.72),(271.16±21.96),and(160.91±15.20)ng/L in the control group(P<0.05).At 3 d after surgery,the transferrin,retinol-binding protein and prealbumin in both groups were decreased compared with before surgery;the observation group had transferrin of(2.97±0.34)g/L,retinol-binding protein of(19.27±1.39)mg/L,and prealbumin of(252.95±16.38)mg/L,which were higher than(2.10±0.25)g/L,(17.19±1.02)mg/L,and(221.03±13.78)mg/L in the control group(P<0.05).At 3 d after surgery,the serum malondialdehyde and oxidized glutathione in both groups were decreased,and the superoxide dismutase and reduced glutathione were increased;the serum malondialdehyde and oxidized glutathione in the observation group were lower than those in the control group,and superoxide dismutase and reduced glutathione were higher than those in the control group(P<0.05).At 3 d after surgery,the levels of motilin and gastrin in both groups were higher than those before surgery,and the levels of all indexes in the observation group were higher than those in the control group(P<0.05)

关 键 词：腹腔镜微创手术 结直肠癌 疼痛介质水平 胃肠道功能 

分 类 号：R73[医药卫生—肿瘤]