替罗非班治疗急性缺血性脑卒中的效果及对生活质量的影响分析  

Effect analysis of tirofiban on acute ischemic stroke and its influence on quality of life

作　　者：隗茂芸[1] 方永[1] 董莹莹 WEI Mao-yun;FANG Yong;DONG Ying-ying(Pharmacy Department,Jinan Third People's Hospital,Jinan 250132,China)

机构地区：[1]济南市第三人民医院药学部,250132

出　　处：《中国现代药物应用》2025年第4期97-100,共4页Chinese Journal of Modern Drug Application

基　　金：2023年济南市第三人民医院科研培育计划项目(项目编号:2023-03)。

摘　　要：目的分析替罗非班治疗急性缺血性脑卒中的效果以及对患者生活质量的影响。方法120例急性缺血性脑卒中患者作为研究对象,采用随机取样法分为对照组和试验组,每组60例。对照组给予神经内科常规治疗+抗血小板治疗,试验组在对照组基础上给予替罗非班治疗。比较两组治疗前后的神经功能缺损程度、生活质量及血小板减少发生情况。结果治疗后1、2个月,两组美国国立卫生研究院卒中量表(NIHSS)评分均低于本组治疗前,且试验组的NIHSS评分(8.47±1.75)、(5.17±0.79)分均低于对照组的(11.63±1.56)、(9.64±1.12)分,差异有统计学意义(P<0.05)。试验组治疗期间血小板减少发生率高于对照组,但差异无统计学意义(P>0.05)。治疗后,两组Barthel指数量表(BI)评分、生活质量指数(QLI)评分均高于本组治疗前,且试验组BI评分(66.57±7.38)分、QLI评分(8.78±1.32)分高于对照组的(56.49±7.61)、(6.27±1.14)分,差异有统计学意义(P<0.05)。结论替罗非班用于急性缺血性脑卒中治疗可有效改善患者的神经功能缺损程度,提升生活质量,具有良好的临床应用效果。Objective To analyze the effect of tirofiban on acute ischemic stroke and its influence on quality of life of patients.Methods 120 patients with acute ischemic stroke were selected as study subjects and divided into control group and experimental group by random sampling method,with 60 cases in each group.The control group was given conventional neurological treatment+antiplatelet therapy,and the experimental group was given tirofiban on the basis of the control group.The degree of neurological deficit,quality of life and thrombocytopenia before and after treatment were compared between the two groups.Results 1 and 2 months after treatment,the National Institutes of Health Stroke Scale(NIHSS)scores in both groups were lower than those before treatment;NIHSS scores in the experimental group were(8.47±1.75)and(5.17±0.79)points,which were lower than(11.63±1.56)and(9.64±1.12)points in the control group;the difference was statistically significant(P<0.05).The incidence of thrombocytopenia in the experimental group was higher than that in the control group,but the difference was not statistically significant(P>0.05).After treatment,the Barthel index(BI)score and quality of life index(QLI)score in both groups were higher than those before treatment;BI score and QLI score were(66.57±7.38)and(8.78±1.32)points in the experimental group,which were higher than(56.49±7.61)and(6.27±1.14)points in the control group,and the difference was statistically significant(P<0.05).Conclusion Application of tirofiban in the treatment of acute ischemic stroke can effectively improve the degree of neurological deficit and improve the quality of life of patients,and has a good clinical application effect.

关 键 词：缺血性脑卒中 替罗非班 神经功能缺损程度 血小板 生活质量 

分 类 号：R74[医药卫生—神经病学与精神病学]