多发性骨髓瘤化疗后患者住院感染危险因素的Meta分析  

Meta-analysis of risk factors of hospitalization infections in patients with multiple myeloma after chemotherapy

作　　者：王玥琳 蒋运兰[2] 李乐 陈红 王镜 张梦洁 白小雨 武森林 WANG Yuelin;JIANG Yunlan;LI Le;CHEN Hong;WANG Jing;ZHANG Mengjie;BAI Xiaoyu;WU Senlin(School of Nursing,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China;Party Committee Office,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China)

机构地区：[1]成都中医药大学护理学院,四川成都610075 [2]成都中医药大学附属医院党委办公室,四川成都6100751

出　　处：《中国现代医生》2025年第6期30-34,94,共6页China Modern Doctor

摘　　要：目的 系统评价多发性骨髓瘤(multiple myeloma,MM)化疗后患者住院感染的影响因素。方法 计算机检索中国知网、中国生物医学文献数据库、维普网、万方数据知识服务平台、PubMed、Web of Science、Embase、Cochrane Library、CINAHL自建库至2024年12月16日的全部相关文献。2名研究者独立筛选、评价文献质量并提取资料,采用RevMan5.4软件对危险因素进行Meta分析。结果 共纳入19篇文献。Meta分析结果显示体质量指数高、住院时间、吸烟史、美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)评分、粒细胞缺乏、中性粒细胞减少、Durie-Salmon分期、多发性骨髓瘤国际分期系统(international staging system,ISS)分期及合并糖尿病、肾功能不全、贫血、低白蛋白血症是MM化疗后患者住院感染的危险因素(P<0.05)。结论 本研究为干预MM患者化疗后住院感染的危险因素提供参考,医护人员应根据相关因素早期预防感染,识别高危人群,最大限度保障患者的健康结局和良好预后。Objective To systematically evaluate influence factors hospitalization infections in multiple myeloma(MM)patients after chemotherapy.Methods Computer searches were conducted on relevant literature in CNKI,China Biology Medicine disc,VIP,Wanfang Data Knowledge Service Platform,PubMed,Web of Science,Embase,Cochrane Library and CINAHL from the database inception until December 16,2024.Two researchers independently screened and assessed the quality of the literature,obtained the necessary information,and a Meta-analysis of risk factors was conducted by using RevMan 5.4 software.Results 19 articles were included in total.Meta-analysis results showed that high body mass index,length of stay,smoking history,Eastern Cooperative Oncology Group(ECOG)score,granulocyte deficiency,neutropenia,Durie-Salmon stage,international staging system(ISS)stage and combined with diabetes,renal insufficiency,anemia,hypoalbuminemia were the risk factors for hospitalization infections in patients with MM after chemotherapy(P<0.05).Conclusion This study provides a reference for intervening in the risk factors of hospitalization infections in MM patients after chemotherapy.Medical staff should prevent infections early based on relevant factors,identify high-risk populations,and maximize the protection of patient health outcomes and good prognosis.

关 键 词：多发性骨髓瘤 化疗 住院感染 危险因素 META分析 

分 类 号：R733.3[医药卫生—肿瘤]