乳腺癌分子分型与超声影像学特征及病理组织学特点的相关性  

Correlation Between Molecular Typing of Breast Cancer and Its Ultrasonographic and Pathological Features

作　　者：乔璐 刘华青 范瑞瑞 张苗 李秀平 李宁 QIAO Lu;LIU Huaqing;FAN Ruirui;ZHANG Miao;LI Xiuping;LI Ning(Department of Ultrasound,International Health Management Center of Zhengzhou Yihe Hospital,Zhengzhou 450000,China;Department of Ultrasound,Henan Provincial People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州颐和医院国际健康管理中心超声科,河南郑州450000 [2]河南省人民医院超声科,河南郑州450000

出　　处：《河南医学研究》2025年第4期632-636,共5页Henan Medical Research

摘　　要：目的探究乳腺癌分子分型与超声影像学特征及病理组织学特点的相关性。方法选取2022年1月至2023年12月医院收治的166例乳腺癌患者,接受二维超声、彩色多普勒血流成像检查,根据病理学结果分组,44例纳入Luminal A型组,78例纳入Luminal B型组,16例纳入人类表皮生长因子受体2(HER-2)过表达型组,28例纳入三阴型组,分析其影像学资料。结果不同分子分型患者病理类型分布情况不同,Luminal A型组多表现为浸润性导管癌(86.36%),Luminal B型组多表现为浸润性导管癌(67.95%),HER-2过表达型组多表现为浸润性导管癌(68.75%),三阴型组多表现为浸润性导管癌(57.14%)。不同分子分型患者的纵横比及边缘是否规整组间差异无统计学意义(P>0.05),边界是否清晰及形态是否规则组间差异有统计学意义(P<0.05),其中,以三阴型组患者边界清晰率、形态规则率最高。不同分子分型患者的钙化情况及钙化形态差异有统计学意义(P<0.05),Luminal A型组、Luminal B型组、HER-2过表达型组、三阴型组钙化发生率分别为36.36%、58.97%、75.00%、25.00%。不同组间患者的血流分级情况及血流速度均值、血流阻力情况差异无统计学意义(P>0.05),其病灶内部及其周边组织弹性值最高的杨氏模量值(Emax)差异有统计学意义,HER-2过表达型组的Emax最高,Luminal A型组的Emax最低;Luminal B型组的Emax-shell-1.0、Emax-shell-2.0、Emax-shell-3.0最高,三阴型组的Emax-shell-1.0、Emax-shell-2.0、Emax-shell-3.0最低(P<0.05)。结论乳腺癌的分子分型与超声表现的钙化特征和弹性模量有明显的相关性,对乳腺癌的诊断和治疗具有潜在的临床意义。Objective To explore the correlation between molecular classification of breast cancer and ultrasound imaging characteristics and pathological histological characteristics.Methods A total of 166 breast cancer patients admitted from January 2022 to December 2023 underwent two-dimensional ultrasound and color Doppler flow imaging,and 44 patients were included in the Luminal A group,78 in the Luminal B group,16 in the human epidermal growth factor receptor 2(HER-2)overexpression group,and 28 were included in the triple group.The imaging data was analyzed.Results The distribution of pathological types varies among patients with different molecular subtypes.Luminal A group was more likely to present with invasive ductal carcinoma(86.36%),Luminal B group was more likely to present with invasive ductal carcinoma(67.95%),HER-2 overexpression group was more likely to present with invasive ductal carcinoma(68.75%),and triple negative group was more likely to present with invasive ductal carcinoma(57.14%).There was no statistically differencein the aspect ratio and whether the edges were regular among patients with different molecular subtypes(P>0.05).There was statistically difference in whether the boundaries were clear and the morphology was regular between groups(P<0.05).Among them,the three negative group had the highest rates of clear boundaries and regular morphology.There were statistically differences in calcification status and morphology among patients with different molecular subtypes(P<0.05).The incidence of calcification in Luminal A group,Luminal B group,HER-2 overexpression group,and triple negative group was 36.36%,58.97%,75.00%,and 25.00%,respectively.There was no statistically difference in the blood flow grading,mean blood flow velocity,and blood flow resistance among patients in different groups(P>0.05).However,there was a statistically significant difference in the Young’s modulus value(Emax)with the highest elasticity value within and around the lesion.The Emax value was highest in the HER-2 overexp

关 键 词：乳腺癌 分子分型 血流分级 弹性模量 钙化 

分 类 号：R737.9[医药卫生—肿瘤]