超声血流定量参数及血清Omentin-1水平与乳腺癌患者病理特征及预后的相关性分析  

Correlation Analysis of Quantitative Ultrasound Blood Flow Parameters and Serum Omentin-1 Levels with Pathological Characteristics and Prognosis in Breast Cancer Patients

作　　者：赵颖 赵宏伟 牛殿英 张娟 ZHAO Ying;ZHAO Hongwei;NIU Dianying;ZHANG Juan(Ultrasound Medicine,Kaifeng Central Hospital,Kaifeng 475000,China;Laboratory,Kaifeng Central Hospital,Kaifeng 475000,China)

机构地区：[1]开封市中心医院超声医学科,河南开封475000 [2]开封市中心医院检验科,河南开封475000

出　　处：《河南医学研究》2025年第4期640-645,共6页Henan Medical Research

摘　　要：目的探讨乳腺癌患者超声血流定量参数、血清网膜素-1(Omentin-1)水平与病理特征相关性,并分析其对预后的预测价值。方法回顾性选取2022年1月至2023年1月开封市中心医院收治的96例乳腺癌患者作为研究对象,分析超声血流定量参数、血清Omentin-1水平与临床病理特征相关性。研究组接受乳腺癌改良根治术治疗,依据术后1 a内生存情况分为预后良好组71例、预后不良组25例,比较其超声血流定量参数、血清Omentin-1水平。分析超声血流定量参数、血清Omentin-1对预后的预测价值。结果EDV、PI、RI与TNM分期、淋巴结转移、脉管侵犯呈正相关,而与分化程度呈负相关(P<0.05);血清Omentin-1与TNM分期、淋巴结转移、脉管侵犯呈负相关,而与分化程度呈正相关(P<0.05);预后不良组术后EDV、PI、RI高于预后良好组,血清Omentin-1水平低于预后良好组(P<0.05);术后2个月EDV、PI、RI、Omentin-1联合预测预后(术后1 a)的曲线下面积(AUC)大于单项指标预测(P<0.05)。结论乳腺癌患者EDV、PI、RI升高,血清Omentin-1水平降低,且与临床病理特征密切相关,联合检测其水平对预后具有一定预测价值。Objective To investigate the correlation between ultrasonic blood flow quantitative parameters,serum Omentin-1 level and clinicopathological characteristics in patients with breast cancer,and to analyze their predictive value for prognosis.Methods A retrospective study was conducted on 96 breast cancer patients in Kaifeng Central Hospital from January 2022 to January 2023.The correlation between quantitative ultrasound blood flow parameters,serum Omentin-1 levels,and clinical pathological characteristics was analyzed.The study group underwent modified radical mastectomy for breast cancer treatment,and was divided into good prognosis group of 71 cases and poor prognosis group of 25 cases based on their survival status within one year after surgery.The quantitative ultrasound blood flow parameters and serum Omentin-1 levels were compared between the two groups,and the predictive value of quantitative ultrasound blood flow parameters and serum Omentin-1 levels for prognosis was analyzed.Results EDV,PI and RI were positively correlated with TNM stage,lymph node metastasis and vascular invasion,but negatively correlated with the degree of differentiation(P<0.05).Serum Omentin-1 was negatively correlated with TNM stage,lymph node metastasis and vascular invasion,but positively correlated with the degree of differentiation(P<0.05).The postoperative EDV,PI,and RI in the poor prognosis group were higher than those in the good prognosis group,and the serum Omentin-1 level was lower than that in the good prognosis group(P<0.05).The area under the curve(AUC)of the combined prediction of EDV,PI,RI,and Omentin-1 for prognosis(1 year after surgery)was greater than that of single indicators(P<0.05).Conclusion EDV,PI,RI in patients with breast cancer are increased,and serum Omentin-1 level is decreased,which is closely related to the clinicopathological characteristics.Combined detection of its level has a certain predictive value for the prognosis.

关 键 词：乳腺癌 超声血流定量参数 网膜素-1 临床病理特征 预后 预测 

分 类 号：R737.9[医药卫生—肿瘤]