IL-10基因多态性与脑梗死患者溶栓后肺部感染的关系  

Relationship Between Polymorphisms of IL-10 Gene and Pulmonary Infection in Patients with Cerebral Infarction After Thrombolysis

作　　者：袁聪 井梦昕 常欢 YUAN Cong;JING Mengxin;CHANG Huan(The Fourth Ward of Department of Neurology,Nanyang Second People’s Hospital,Nanyang 473009,China)

机构地区：[1]南阳市第二人民医院神经内科四病区,河南南阳473009

出　　处：《河南医学研究》2025年第4期675-679,共5页Henan Medical Research

摘　　要：目的探讨白细胞介素-10(IL-10)基因多态性与脑梗死患者溶栓后肺部感染的关系。方法选取南阳市第二人民医院2019年9月至2022年9月收治的138例脑梗死患者,所有患者均接受溶栓治疗,依照患者住院期间肺部感染发生情况,将患者分为肺部感染组(30例)与无肺部感染组(108例),对IL-10启动区域-1082、-819、-592基因分型进行检测,比较肺部感染组和无肺部感染组基因型频率,分析IL-10基因多态性与脑梗死溶栓后继发肺部感染风险的关联性。结果30例肺部感染患者共分离出42株病原菌,其中革兰阴性菌(30株,71.43%)占比高于革兰阳性菌(10株,23.81%)、真菌(2株,4.76%)(P<0.05)。肺部感染组IL-10-1082位点AG基因型、-592位点中AA基因型比率高于无肺部感染组;肺部感染组与无肺部感染组-819基因型及基因频率分布比较,差异无统计学意义(P>0.05)。logistic多因素分析结果显示IL-10-1082 AG与GG型基因型是患者继发肺部感染的危险基因型,OR值为1.806(95%CI:1.106~2.948);IL-10-592 AA基因型是患者继发肺部感染的危险基因型,OR值为1.637(95%CI:1.176~2.280)。结论IL-10启动区域-1082 AG与GG型基因型以及-592 AA基因型是脑梗死患者继发肺部感染的易感基因。Objective To explore the relationship between polymorphisms of interleukin-10(IL-10)gene and pulmonary infection in patients with cerebral infarction after thrombolysis.Methods A total of 138 patients with cerebral infarction undergoing thrombolysis in Nanyang Second People’s Hospital were enrolled between September 2019 and September 2022.According to presence or absence of pulmonary infection during hospitalization,they were divided into pulmonary infection group(30 cases)and non-infection group(108 cases).The genotyping test was conducted for IL-10 promoter region at-1082,-819 and-592 loci.The frequencies of genotypes were compared between pulmonary infection group and non-infection group.The correlation between IL-10 gene polymorphism and pulmonary infection risk in cerebral infarction after thrombolysis was analyzed.Results In the 30 patients with pulmonary infection,there were 42 strains of pathogens,including 30 strains(71.43%)of Gram-negative bacteria,more than Gram-positive bacteria[10 strains(23.81%)]and fungus[2 strain(4.76%)](P<0.05).The proportion of AG genotype in IL-10 promoter region at-1082 locus in pulmonary infection group was higher than that in non-infection group,and the proportion of AA genotype at-592 locus was higher than that in non-infection group.There was no significant difference in the genotype and gene frequency of-819 between pulmonary infection group and non-infection group(P>0.05).The results of logistic multivariate analysis showed that AG and GG genotypes of IL-10-1082 were the risk genotypes of pulmonary infection[OR=1.806(95%CI:1.106-2.948)].AA genotype of IL-10-592 was the risk genotype of pulmonary infection[OR=1.637(95%CI:1.176-2.280)].Conclusion AG and GG genotypes at-1082 locus,and AA genotype at-592 locus of IL-10 promoter region are susceptibility genes of pulmonary infection in patients with cerebral infarction.

关 键 词：脑梗死 溶栓效果 肺部感染风险 白细胞介素-10 基因多态性 关联性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]