双相情感障碍躁狂发作患者血清多巴胺甲状腺激素与认知功能的关系  

Relationship of serum dopamine and thyroid hormones with cognitive function in patients with manic episode of bipolar disorder

作　　者：杨旭宁 吕晓静 李晓红 Yang Xuning;Lv Xiaojing;Li Xiaohong(Henan Provincial Rongkang Hospital,Luoyang 471000,Henan,China)

机构地区：[1]河南省荣康医院,河南洛阳471000

出　　处：《临床心身疾病杂志》2025年第2期10-13,共4页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 探讨双相情感障碍(BD)躁狂发作患者血清多巴胺(DA)、甲状腺激素水平与认知功能的关系。方法 检测104例BD躁狂发作患者(研究组)和100名健康人员(对照组)的血清DA及甲状腺激素[促甲状腺激素(TSH)、甲状腺素(T_(4))、游离T_(4)(FT_(4))、三碘甲状腺原氨酸(T_(3))、游离T_(3)(FT_(3))]水平。采用蒙特利尔认知评估量表(MoCA)评定研究组患者的认知功能,采用单因素分析及Logistic回归分析探讨血清DA及甲状腺激素与认知功能的关系。结果 研究组受试者血清DA、T_(4)、FT_(4)、T_(3)、FT_(3)水平高于对照组,TSH水平低于对照组(P<0.01)。BD躁狂发作患者认知功能障碍发生率为40.38%。存在认知功能障碍的患者体质量指数、病程及血清DA、TSH、T_(4)、FT_(4)、T_(3)、FT_(3)水平与认知功能正常患者比较,差异均有统计学意义(P<0.05或0.01)。Logistic回归分析显示,血清DA、TSH、T_(4)、FT_(4)、T_(3)、FT_(3)是影响BD躁狂发作患者认知功能的相关因素(P<0.01)。结论 BD躁狂发作患者血清DA及甲状腺激素表达水平异常,且与患者认知功能有关,临床应定期检测上述指标,以便更好地预防或改善患者的认知功能。Objective To explore the relationship of serum dopamine(DA)and thyroid hormone with cognitive function in patients with manic episode of bipolar disorder(BD).Methods Serum DA and thyroid hormone(thyroid stimulating hormone[TSH],thyroxine[T_(4)],free T_(4)[FT_(4)],triiodothyronine[T_(3)],free T_(3)[FT_(3)])levels were detected in 104 patients with BD manic episode(research group)and 100 healthy persons(control group).Cognitive functions were assessed for patients in research group using the Montreal Cognitive Assessment(MoCA),the relationships of serum dopamine and thyroid hormones with cognitive function explored using single-factor and Logistic regression analysis.Results Serum DA,T_(4),FT_(4),T_(3) and FT_(3) level were higher and TSH was lower in research than control group(P<0.01).The incidence of cognitive impairment in patients with BD manic episode was 40.38%.Differences in body mass index,course of disease as well as serum DA,T_(4),FT_(4),T_(3) and FT_(3) level between patients with cognitive impairment and ones with normal cognitive functions were statistically significant(P<0.05 or 0.01).Logistic regression analysis showed that DA,TSH,T_(4),FT_(4),T_(3) and FT_(3) were related factors affecting cognitive function in patients with BD manic episodes(P<0.01).Conclusion Serum DA and thyroid hormone in patients with BD manic episode express abnormally,which is related to cognitive functions of patients,above-mentioned indicators should be regularly detected in clinic so as to better prevent or improve the cognitive functions of patients.

关 键 词：双相情感障碍 躁狂发作 多巴胺 甲状腺激素 认知功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学]