抗雄药物撤退治疗对去势抵抗性前列腺癌患者认知功能的影响  

Effect of Antiandrogen Withdrawal Therapy on Cognitive Function in Castration-resistant Prostate Cancer Patients

作　　者：韩晶晶 HAN Jingjing(Anyang Cancer Hospital,Anyang Henan 455000)

机构地区：[1]安阳市肿瘤医院,河南安阳455000

出　　处：《医学临床研究》2025年第2期200-203,共4页Journal of Clinical Research

摘　　要：【目的】探讨抗雄药物撤退治疗对去势抵抗性前列腺癌(CRPC)患者认知功能的影响。【方法】回顾性分析2018年2月至2023年3月本院收治的100例去势抵抗性前列腺癌患者的临床资料,根据患者是否进行抗雄药物撤退治疗分为观察组和对照组,每组50例。比较两组患者蒙特利尔认知评估量表(MoCA)评分、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、神经心理认知功能测试情况[听觉词语学习测试(AVLT)、数字广度测试(DS)、连线任务测试(TMT)、词汇流畅性测试(VF)、经典Stroop范式测试],采用Pearson相关分析抗雄药物撤退治疗结果与患者认知功能损害程度的相关性。【结果】观察组患者MoCA评分显著低于对照组,HAMA、HAMD评分均高于对照组,差异有统计学意义(P<0.05)。观察组患者再认记忆评分、顺背数字评分低于对照组,经典Stroop范式C测验用时、TMT A测验用时、TMT B测验用时均长于对照组,差异均有统计学意义(P<0.05)。Pearson相关分析显示,抗雄药物撤退治疗结果与患者的认知功能、焦虑状态、再认记忆能力呈正相关(P<0.05),与TMT A测验用时、TMT B测验用时呈负相关(P<0.05)。【结论】抗雄药物撤退治疗的CRPC患者存在认知功能、再认记忆能力、顺背数字广度、执行功能、信息处理能力下降,焦虑及抑郁情绪的情况,对于CRPC患者应用抗雄药物撤退治疗过程中应注重启动前及治疗过程中的干预措施,可改善患者的认知功能。【Objective】To investigate the effect of antiandrogen withdrawal therapy on cognitive function in castration-resistant prostate cancer(CRPC).【Methods】The clinical data of 100 patients with castration-resistant prostate cancer admitted to our hospital from February 2018 to March 2023 were retrospectively analyzed,and they were divided into the observation group and the control group according to whether the patients were treated with antiandrogynous drug withdrawal,with 50 cases in each group.The score of Montreal Cognitive Assessment Scale(MoCA),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)and neuropsychological cognitive function test[Auditory Word Learning Test(AVLT),Number Range Test(DS),Connected Task Test(TMT),Verbal Fluency Test(VF),Classic Stroop paradigm test]were compared between the two groups.Pearson correlation was used to analyze the correlation between the outcome of antiandrogenic drug withdrawal and the degree of cognitive impairment.【Results】MoCA scores in the observation group were significantly lower than those in the control group,and HAMA and HAMD scores were higher than those in the control group,with statistical significance(P<0.05).The recognition memory score and anteroposteric number score in the observation group were lower than those in the control group,and the time of classic Stroop paradigm C test,TMT A test and TMT B test were longer than those in the control group,with statistical significance(P<0.05).Pearson correlation analysis showed that the results of antiandrogant withdrawal treatment were positively correlated with cognitive function,anxiety state and recognition memory ability of patients(P<0.05),and negatively correlated with TMT A test time and TMT B test time(P<0.05).【Conclusion】CRPC patients treated with antiandrogen withdrawal showed decreased cognitive function,recognition memory ability,anterograde digital breadth,executive function,information processing ability,and increased anxiety and depression.For CRPC patients treated with antian

关 键 词：前列腺肿瘤 去势难治性 雄激素拮抗药 认知 

分 类 号：R737.25[医药卫生—肿瘤]