奥替溴铵联合幽门螺杆菌根治方案对功能性消化不良患者胃肠激素水平的影响  

The Effect of Otilonium Bromide Combined with Helicobacter Pylori Eradication Therapy on Gastrointestinal Hormone Levels in Patients with Functional Dyspepsia

作　　者：陈睿 王晓松 蒋波 CHEN Rui;WANG Xiaosong;JIANG Bo(Department of Gastroenterology,Suqian Hospital of Jiangsu Province People's Hospital(Suqian First People's Hospital),Suqian Jiangsu 223800)

机构地区：[1]江苏省人民医院宿迁医院(宿迁市第一人民医院)消化内科,江苏宿迁223800

出　　处：《医学临床研究》2025年第2期211-213,217,共4页Journal of Clinical Research

基　　金：宿迁市科技项目(KY202308)。

摘　　要：【目的】探讨奥替溴铵联合幽门螺杆菌(HP)根治方案对功能性消化不良(FD)患者胃肠激素水平的影响。【方法】88例FD患者,随机分为观察组和对照组,每组44例。对照组采取HP根治方案,观察组采取奥替溴铵联合HP根治方案,比较两组患者临床疗效、不良反应发生情况,治疗前后胃肠激素水平、胃动力学指标、生活质量。【结果】观察组总有效率为95.45%,高于对照组的79.55%(P<0.05)。两组治疗后各胃肠激素水平、胃动力学指标较治疗前显著改善,且观察组改善程度优于对照组(P<0.05)。两组治疗后生活质量各项评分较治疗前升高,且观察组高于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。【结论】奥替溴铵联合HP根治方案治疗FD能明显改善患者胃肠激素水平、胃动力学指标,提高疗效及生活质量,且具有一定的安全性。【Objective】To explore the effect of otilonium bromide combined with Helicobacter pylori(HP)eradication therapy on gastrointestinal hormone levels in patients with functional dyspepsia(FD).【Methods】A total of 88 FD patients were randomly divided into the observation group and the control group,with 44 cases in each group.Patients in the control group received HP eradication therapy,while those in the observation group received otilonium bromide combined with HP eradication therapy.The clinical efficacy,adverse reactions,gastrointestinal hormone levels,gastric motility indicators,and changes in quality of life before and after treatment were compared between the two groups.【Results】The total effective rate in the observation group was 95.45%,which was higher than that of the control group(79.54%,P<0.05).After treatment,the gastrointestinal hormone levels and gastric motility in both groups significantly improved compared to before treatment,and the improvement in the observation group was better than that in the control group(P<0.05).After treatment,the quality of life scores in both groups increased compared to before treatment,while the score of quality of life in the observation group was higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).【Conclusion】Otilonium bromide combined with HP eradication therapy significantly improves gastrointestinal hormone levels,gastric motility indicators,clinical efficacy,and quality of life in FD patients,with a certain level of safety.

关 键 词：消化不良 毒蕈碱拮抗剂 幽门螺杆菌 胃肠激素类 

分 类 号：R573[医药卫生—消化系统]