消风散结汤加减治疗小儿腺样体肥大临床研究  

Clinical Research on Modified Wind-Dispersing and Nodules-Dissipating Decoction in the Treatment of Adenoid Hypertrophy in Children

作　　者：王丹凤 杨亚峰 WANG Danfeng;YANG Yafeng(Zhengzhou Traditional Chinese Medicine Hospital,Zhengzhou,Henan,China,450000)

机构地区：[1]郑州市中医院,河南郑州450000

出　　处：《河南中医》2025年第3期414-418,共5页Henan Traditional Chinese Medicine

基　　金：国家中医药管理局科研基金项目(2024ZY3098)。

摘　　要：目的:观察伏邪理论指导下采用消风散结汤加减治疗小儿腺样体肥大的临床疗效。方法:选取2022年1月至2023年12月在郑州市中医院进行治疗的腺样体肥大患儿154例,将其随机分为研究组和对照组,对照组采用常规西药治疗,研究组给予消风散结汤加减治疗。比较两组患儿的临床疗效及治疗前后中医证候积分、血清指标和生活质量变化情况。结果:研究组有效率为93.51%,对照组有效率为74.03%,研究组有效率高于对照组,差异有统计学意义(P<0.05);研究组患儿治疗后鼻塞打鼾、张口呼吸、胸闷憋气、呼吸反复暂停和嗜睡评分均低于对照组,差异有统计学意义(P<0.05);研究组患儿治疗后血清特异性IgE(seryn soecufuc IgE,SIgE)、可溶性白介细胞素-2受体(soluble interleukin-2 receptor,sIL-2R)、肿瘤坏死因子(tumor necrosis factor,TNF)-α和白细胞介素(interleukin,IL)-4水平均低于对照组,差异有统计学意义(P<0.05);研究组患儿治疗后生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论:在伏邪理论指导下采用消风散结汤加减治疗小儿腺样体肥大,能够有效提高治疗效果,改善患儿中医证候积分、血清指标,提高生活质量。Objective:To observe the clinical efficacy of Modified Wind-Dispersing and Nodules-Dissipating Decoction on adenoid hypertrophy in children under the guidance of the theory of latent pathogenic factors.Methods:A total of 154 children who underwent treatment for adenoid hypertrophy in our hospital from January 2022 to December 2023 were randomly divided into the study group and the control group.The children in the control group were treated with conventional Western medicine,while those in the study group were treated with Modified Wind-Dispersing and Nodules-Dissipating Decoction.The clinical efficacy,changes in TCM syndrome scores,serum indicators,and quality of life before and after treatment were compared between the two groups.Results:The effective rate of the study group was 93.51%,while that of the control group was 74.03%.The effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of nasal congestion and snoring,mouth breathing,chest tightness and shortness of breath,repeated breathing pauses and drowsiness of the children in the study group were all lower than those of the control group,and the differences were statistically significant(P<0.05);the levels of SIgE,sIL-2R,TNF-αand IL-4 of the children in the study group were all lower than those of the control group,and the differences were statistically significant(P<0.05);the quality of life scores of the children in the study group were higher than those of the control group,and the difference was statistically significant(P<0.05).Conclusion:Under the guidance of the theory of latent pathogenic factors,Modified Wind-Dispersing and Nodules-Dissipating Decoction is effective in treating adenoid hypertrophy in children,can significantly improve the therapeutic outcome,reduce the TCM syndrome scores and serum indicators,and enhancing their quality of life.

关 键 词：小儿腺样体肥大 伏邪理论 消风散结汤 

分 类 号：R272.9[医药卫生—中医儿科学]