黄酮类化合物抗菌增效作用及机制研究进展  

Research progress on the antibacterial synergistic effects and mechanisms of flavonoids

作　　者：伊蓝坤 陈旭 白玉彬 王玮玮 魏小娟[1] 张志锦 俞筱妍 朱阵 张继瑜[1] YI Lankun;CHEN Xu;BAI Yubin;WANG Weiwei;WEI Xiaojuan;ZHANG Zhijin;YU Xiaoyan;ZHU Zhen;ZHANG Jiyu(Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences,Key Laboratory of Veterinary Pharmaceutical Development,Ministry of Agriculture,Key Laboratory of New Animal Drug Project of Gansu Province,Lanzhou 730050,China;Shool of Life Sciences and Food Engineering,Hebei University of Engineering,Handan 056038,China)

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所/农业农村部兽用药物创制重点实验室/甘肃省新兽药重点实验室,兰州730050 [2]河北工程大学生命科学与食品工程学院,河北邯郸056038

出　　处：《黑龙江畜牧兽医》2025年第3期21-27,共7页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家重点研发计划项目“临潭县肉羊产业提质增效关键技术集成与示范”(2022YFD1602201);国家肉牛牦牛产业技术体系项目(CARS-37);国家自然科学基金项目(32202860);中国农业科学院创新工程项目(25-LZIHPS-05);河北省重点研发项目(22326617D)。

摘　　要：细菌耐药性已经严重威胁畜牧养殖业的健康可持续发展,新型抗菌药物研发成为研究热点。而新型抗生素的研发周期长、成本高且难度大,因此,植物活性成分越发引起人们关注。黄酮类化合物作为植物中最大的一类次生代谢产物,在自然界中广泛存在,目前已被证实具有良好的抗菌活性,且作为抗菌增效剂使用能消减细菌耐药性,增强抗生素治疗效果,是控制细菌耐药性发展的一个新方向。本文结合近年来的相关文献总结了黄酮类化合物的多种药理作用,针对其抑菌作用和抑菌机制展开综述,同时探索黄酮类化合物与抗生素的协同作用,并总结协同作用机制,以期恢复或增强耐药菌对抗生素的敏感性,为将黄酮类化合物开发成为新型抗菌药物或抗菌增效剂提供理论参考。Bacterial resistance has seriously threatened the healthy and sustainable development of the animal husbandry industry,making the research and development of new antibacterial drugs a research hotspot.However,the development of new antibiotics is time-consuming,costly and challenging.Therefore,plant active ingredients have attracted more and more attention.As the largest class of secondary metabolites in plants,flavonoids are widely distributed in nature and have been proven to exhibit siginficant antibacterial activity.Additionally,when used as antibacterial synergists,flavonoids can reduce bacterial resistance and enhance the efficacy of antibiotic,presenting a new direction in controlling the development of bacterial resistance.Based on literature analysis in recent years,this article summarized the various pharmacological activities of flavonoids,reviewed their antibacterial effects and antibacterial mechanisms,and explored the synergistic effects between flavonoids and antibiotics.Moreover,the mechanism underlying this synergy were discussed,aiming to restore or enhance the sensitivity of resistant bacteria to antibiotics,and provide a theoretical reference for the development of flavonoids as new antibacterial drugs or antibacterial synergists.

关 键 词：黄酮类化合物 抗菌机制 抗生素 协同抗菌 协同机制 

分 类 号：S853.74[农业科学—临床兽医学]