铜纳米颗粒@富勒醇复合物的制备及其抗氧化和修护性  

Synthesis and antioxidative repair of copper nanoparticles@fullerenol complex

作　　者：万洁 张立青 张琼 洪流[1,2] 杨成 WAN Jie;ZHANG Liqing;ZHANG Qiong;HONG Liu;YANG Cheng(School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122,Jiangsu,China;Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,Wuxi 214122,Jiangsu,China)

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122 [2]合成与生物胶体教育部重点实验室,江苏无锡214122

出　　处：《精细化工》2025年第3期530-536,共7页Fine Chemicals

基　　金：江苏省自然科学基金项目(BK2017175)。

摘　　要：以富勒醇和CuCl_(2)•2H_(2)O为原料,通过光化学还原法制备了铜纳米颗粒@富勒醇复合物(简称复合物)。利用FTIR、TGA、TEM、XPS和动态光散射(DLS)对富勒醇和复合物的组成结构、微观形貌和粒径分布进行了表征和测试。采用1,1-二苯基-2-三硝基苯肼(DPPH)自由基清除实验与斑马鱼损伤修复模型实验探究了复合物的抗氧化与生物修护性。结果表明,富勒醇的化学分子式为C_(60)(OH)_(24)•11H_(2)O,平均粒径为8.6 nm的铜纳米颗粒成功地包覆在富勒醇表面,形成了平均粒径约为534 nm的复合物;质量浓度为0.1 g/L的复合物水分散液对DPPH自由基抑制率趋近100%,半抑制质量浓度为0.0145 g/L;质量分数为6.25×10^(–5)的复合物抗炎修护功效最佳,修护功效为55%。Copper nanoparticles@fullerenol complex(for short complex)was synthesized from photochemical reduction of fullerenol and CuCl_(2)•2H_(2)O.The fullerenol and complex were then characterized by FTIR,TGA,TEM,XPS and dynamic light scattering(DLS)for analyses on composition,morphology and particle size distribution.The antioxidant and biological repair properties of the complex were further analyzed through 1,1-diphenyl-2-picryl hydrazyl(DPPH)free radicals scavenging experiment and zebrafish damage repair model experiment.The results showed that chemical formula of fullerenol was C_(60)(OH)_(24)•11H_(2)O,while copper nanoparticles with an average particle size of 8.6 nm were successfully coated on the surface of fullerenol,forming a complex with an average particle size of about 534 nm.The composite with a mass concentration of 0.1 g/L could scavenge nearly 100%DPPH free radicals,with half maximal inhibitory concentration(IC_(50))of 0.0145 g/L.And the complex with a mass fraction of 6.25×10^(-5) showed the best anti-inflammatory repair effect of 55%.

关 键 词：富勒醇 铜纳米颗粒 抗氧化性 自由基 生物修护 功能材料 

分 类 号：TB332[一般工业技术—材料科学与工程]