SARS-CoV-2变异株感染啮齿类动物模型的研究进展  

Research progress on rodent models infected by SARS-CoV-2 variant strains

作　　者：王如玉 孙凯丽(综述) 卢佳(审校) WANG Ruyu;SUN Kaili;LU Jia(Biosafety LevelⅢLaboratory,Wuhan Institute of Biological Products Co.,Ltd.,Wuhan 430000,Hubei Province,China)

机构地区：[1]武汉生物制品研究所有限责任公司生物安全三级实验室,湖北武汉430000

出　　处：《中国生物制品学杂志》2025年第2期215-220,共6页Chinese Journal of Biologicals

基　　金：湖北省科技重大专项(2020YFC0842100,2021ACB005)。

摘　　要：由SARS-CoV-2引起的感染是一种影响范围十分广泛的流行性疾病。啮齿类动物模型在研究SARS-CoV-2感染的发病机理、免疫应答及研发治疗与预防药物或疫苗中起到十分重要的作用。但SARS-CoV-2突变的累积及其在人群中的快速传播导致产生了逃避宿主免疫反应的变异株,现有的SARS-CoV-2疫苗可能无法有效控制变异株的传播,因此,针对变异株预防与治疗的疫苗、药物的研发会一直持续。啮齿类动物对于研究病毒病因、传播和发病机制至关重要,同时在早期灭活疫苗及抗体的研发中发挥了重要作用。本文对啮齿类动物模型在SARS-CoV-2 Alpha、Beta、Gamma、Delta、Omicron变异株中的研究进展作一综述。The infection caused by SARS-CoV-2 is a very widespread epidemic disease.Rodent models have played an important role in studying the pathogenesis and immune response of SARS-CoV-2 infection,as well as in developing drugs or vaccines for treatment and prevention.However,the accumulation of SARS-CoV-2 mutations and their rapid spread in the population have led to the emergence of mutant strains that evade host immune responses.The current SARS-CoV-2 vaccine may not be able to effectively control the spread of mutant strains,so the research and development of vaccines and drugs for the prevention and treatment of mutant strains will continue.Rodents are crucial to the study of virus etiology,transmission and pathogenesis,and have played an important role in the early development of related inactivated vaccines and antibodies.This review mainly summarizes the research progress of rodent models in SARS-CoV-2 Alpha,Beta,Gamma,Delta,Omicron mutants.

关 键 词：SARS-CoV-2 变异株 啮齿类动物 感染模型 

分 类 号：R-332[医药卫生]