Combined therapy of a case of multiple venous malformation with FLT4 gene mutation  

作　　者：Yang Yang Ningyuan Gao Ming Ren Lu Wang Zixu Gao Rongkui Luo Chuanyuan Wei Jianying Gu 

机构地区：[1]Department of Plastic and Reconstructive Surgery,Zhongshan Hospital of Fudan University,Shanghai,200032,China [2]Department of Pathology,Zhongshan Hospital of Fudan University,Shanghai,200032,China

出　　处：《Chinese Journal of Plastic and Reconstructive Surgery》2025年第1期18-22,共5页中国整形与重建外科(英文)

基　　金：supported by the National Natural Science Foundation of China(grant no.82272891).

摘　　要：As the study of vascular anomalies progresses,it is imperative for plastic surgeons to individualize their in-depth research and practice to develop more effective and personalized treatment plans.Recent advancements in genome sequencing technology have highlighted the importance of vascular endothelial growth factor(VEGF)and its receptor(VEGFR)in the formation and alteration of vascularity.However,definitive reports regarding mutations associated with this locus and treatment experiences remain scarce.Herein,we report a clinical case of multiple venous malformations with mutations in VEGFR3(FLT4).We implemented a comprehensive approach,including local lesion excision of the left foot and trunk,oral propranolol administration,and local physiotherapy.After two years of follow-up,the patient’s left foot venous malformation did not recur,and he expressed satisfaction with the outcomes of the combined therapy.This case offers valuable insights into the clinical management of this mutant type and similar presentations of multiple venous malformations.

关 键 词：Multiple venous malformations Whole-exome sequencing FLT4 mutations 

分 类 号：R363[医药卫生—病理学]