临床问题驱动的肿瘤研究新范式  

A Clinical Practice-Driven Novel Paradigm of Tumor Research

作　　者：朱波 石嵘 姚刚 张旭[3] 陈孝平 王红阳 Bo Zhu;Rong Shi;Gang Yao;Xu Zhang;Xiaoping Chen;Hongyang Wang(Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China;Department of Health Sciences,National Natural Science Foundation of China,Beijing 100085,China;Department of Urology,Chinese PLA General Hospital,Beijing 100089,China;Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Eastern Hepatobiliary Surgery Hospital,Naval Medical University,Shanghai 201712,China)

机构地区：[1]陆军军医大学第二附属医院(新桥医院),重庆400037 [2]国家自然科学基金委员会医学科学部,北京100085 [3]中国人民解放军总医院泌尿外科医学部,北京100089 [4]华中科技大学同济医学院,武汉430030 [5]海军军医大学第三附属医院(上海东方肝胆外科医院),上海201712

出　　处：《中国科学基金》2025年第1期2-13,共12页Bulletin of National Natural Science Foundation of China

摘　　要：恶性肿瘤是威胁人民生命健康的重大疾病,不仅给患者带来巨大痛苦,也给社会经济发展造成了沉重负担。我国肿瘤患者五年生存率远低于欧美国家,凸显出我国肿瘤防控工作仍有待加强。当今世界正进入大科学时代,肿瘤研究既迎来了前所未有的机遇,也面临着诸多挑战。传统的以知识探索为导向的研究范式限制了科研成果向临床应用的有效转化。为提升肿瘤科研转化效率,提升我国肿瘤防治综合实力,国家自然科学基金委员会成功举办了双清论坛“临床问题驱动的肿瘤研究新范式”。此次论坛深刻剖析了肿瘤预防、诊断、治疗及药物研发等领域的核心难题,并深入探讨了“肿瘤研究新范式”的核心内涵与显著特征。本文旨在总结论坛达成的共识,概述肿瘤防治的现状、面临的重大科学问题、传统范式的局限性以及新范式的内涵特征,为推动我国肿瘤研究高质量发展和科学基金前瞻布局提供理论支撑。Malignant tumors pose a significant public health threat,causing considerable morbidity and mortality,while also imposing a substantial burden on socio-economic development.In China,the fiveyear survival rate for cancer patients remains markedly lower than that in Europe and North America,highlighting the urgent need to strengthen national cancer prevention and control strategies.Currently,the world has entered the era of big data,and tumor research is presented with both unprecedented opportunities and substantial challenges.Traditional research models,which prioritize basic knowledge discovery,have hindered the effective translation of scientific findings into clinical practice.To address this gap and enhance the efficiency of tumor research translation,the National Natural Science Foundation of China organized the“New Paradigm of Tumor Research Driven by Clinical Problems”Shuang-Qing Forum.The forum critically addressed key challenges in tumor prevention,diagnosis,treatment,and drug development,while exploring the essential principles and unique characteristics of the emerging“new paradigm”in tumor research.This article seeks to summarize the key outcomes of the forum,provide an overview of the current state of cancer prevention and treatment in China,discuss major scientific challenges,critique the limitations of traditional research paradigms,and outline the goals and features of the new paradigm.Ultimately,it aims to offer theoretical insights to support the high-quality development of tumor research in China and inform the forward-looking allocation of scientific funding.

关 键 词：肿瘤防治 临床问题 转化研究 新范式 

分 类 号：R730.5[医药卫生—肿瘤]