肿瘤临床科学研究新范式  

A New Paradigm for Clinical Cancer Research

作　　者：樊嘉[1] 高强[1] 董良庆 Jia Fan;Qiang Gao;Liangqing Dong(Department of Liver Surgery and Transplantation,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院肝胆肿瘤与肝移植外科,上海200032

出　　处：《中国科学基金》2025年第1期14-23,共10页Bulletin of National Natural Science Foundation of China

摘　　要：伴随着生命科学技术的飞速发展,临床肿瘤学的科研范式的转变引领着前所未有的创新突破,数据驱动型科研方法已经成为推动肿瘤研究的核心力量,从传统的还原论思维到如今的多维度组学数据分析和高通量靶点筛选验证,正迎来类似历史性转折。尤其是在肝癌诊治领域,基础研究与临床实践的深度融合,推动了肝癌突破性创新与渐进性演化协同促进的“双轨驱动”新科学范式的发展,并在早期筛查、新治疗靶点挖掘以及个体化诊治方面都取得显著进展。新的临床科研范式正以前所未有的速度重塑肿瘤学的前沿,助力突破了传统科研范式的局限,为肿瘤诊疗开辟了创新路径。With the rapid advancement of life sciences and technology,the paradigm shift in clinical oncology research is leading to unprecedented breakthroughs.Data-driven research methodologies have become the central force driving cancer research,particularly in the field of liver cancer.From traditional reductionist thinking to the current multi-dimensional omics data analysis and high-throughput target screening and validation,oncology research is undergoing a historic transformation.The deep integration of basic research and clinical practice has fostered a new scientific paradigm of“dual-track propulsion”,where groundbreaking innovations in basic research are synergistically promoting progressive advancements in clinical treatments.This paradigm has led to significant progress in cancer screening and early detection,the discovery of new therapeutic targets,and personalized diagnosis and treatment.Science advancements are reshaping the frontiers of oncology at an unprecedented pace,overcoming the limitations of traditional research paradigms,and opening innovative pathways for cancer diagnosis and treatment.

关 键 词：科学研究范式 数据驱动 突破性研究 渐进性研究 精准医学 

分 类 号：R730[医药卫生—肿瘤]