肿瘤生物标志物高灵敏组学检测技术  

Highly Sensitive Omics-based Detection Technologies for Tumor Biomarkers

作　　者：乔思圆 程林[2] 韩达 Siyuan Qiao;Lin Cheng;Da Han(Institute of Molecular Medicine,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou 310022,China)

机构地区：[1]上海交通大学医学院分子医学研究院,上海200127 [2]中国科学院杭州医学研究所,杭州310022

出　　处：《中国科学基金》2025年第1期162-173,共12页Bulletin of National Natural Science Foundation of China

基　　金：国家自然科学基金项目(22225402)的资助。

摘　　要：肿瘤生物标志物是一类由肿瘤细胞或宿主对肿瘤反应产生的物质。与传统的组织活检等检测方法相比,基于肿瘤生物标志物的液体活检技术展现出低侵入性、高便利性等优势,在临床肿瘤诊断中起到了不可替代的作用。近年来,随着组学研究的快速发展和检测技术的不断完善,高灵敏的检测技术使得体液中的肿瘤生物标志物能够被静态检测和动态监测,这不仅深化了我们对肿瘤微环境变化的理解,也为癌症的早期诊断、进展监测和疗效评估提供了关键信息。本文旨在从组学视角对肿瘤生物标志物的高敏感检测技术进行综述,并探讨这些技术的原理、特点以及在癌症诊疗中的应用价值。Tumor biomarkers are substances produced by tumor cells or the bodys responses to tumors.Compared with traditional detection methods such as tissue biopsy,liquid biopsy based on tumor biomarkers offers advantages such as low invasiveness and high convenience,which plays an irreplaceable role in clinical tumor diagnosis.In recent years,with the rapid development of omics research and continuous improvements in detection technologies,highly sensitive technologies have enabled the static detection and dynamic monitoring of tumor biomarkers in body fluids.It not only deepens our understanding of changes in the tumor microenvironment,but also provides crucial information for early diagnosis,progression monitoring and efficacy evaluation of cancers.Herein,we aim to review highly sensitive detection technologies for tumor biomarkers from the perspective of omics and discuss the principles,characteristics and clinical application values of these technologies in cancer diagnosis and treatment.

关 键 词：肿瘤生物标志物 高灵敏检测 组学技术 液体活检 精准诊疗 

分 类 号：R730.43[医药卫生—肿瘤]