MRI灌注成像联合血清SAA、TFF1检测对肉芽肿性乳腺炎与非肿块型乳腺癌的鉴别价值  

Value of MRI perfusion imaging combined with serum SAA and TFF1 detection in differentiating granulomatous mastitis from non⁃mass breast cancer

作　　者：周钰[1] 张鑫 文颖 刘佳[3] 许源[4] ZHOU Yu;ZHANG Xin;WEN Ying;LIU Jia;XU Yuan(Department of Radiology,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei,China,430050;Department of Medical Imaging,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan,Hubei,China,430064;Department of Gynecology,,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei,China,430050;Department of Clinical Laboratory,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei,China,430050)

机构地区：[1]武汉市中医医院放射科,湖北武汉430050 [2]武汉科技大学附属天佑医院医学影像科,湖北武汉430064 [3]武汉市中医医院妇科,湖北武汉430050 [4]武汉市中医医院检验科,湖北武汉430050

出　　处：《分子诊断与治疗杂志》2025年第1期88-91,共4页Journal of Molecular Diagnostics and Therapy

基　　金：湖北省自然科学基金资助项目(202309369)。

摘　　要：目的探讨MRI灌注成像联合血清淀粉样蛋白A(SAA)、三叶因子1(TFF1)检测在肉芽肿性乳腺炎(GM)与非肿块型乳腺癌(NMBC)中的鉴别价值。方法选取2019年8月至2023年8月于武汉市中医医院进行乳腺MRI检查的患者112例,GM患者54例纳入GM组,NMBC患者58例纳入NMBC组。检测两组血清SAA、TFF1表达水平;采用受试者工作特征(ROC)曲线分析MRI灌注成像联合SAA、TFF1鉴别GM与NMBC的价值;采用Kappa检验分析与病理结果的一致性。结果GM组Kep、Ktrans、CER及EER值高于NMBC组,差异有统计学意义(P<0.05);GM组SAA、TFF1值低于NMBC组,差异有统计学意义(P<0.05);ROC曲线显示,MRI灌注参数Kep、Ktrans、CER、EER值、MRI、血清SAA、TFF1、MRI+SAA+TFF1诊断GM的曲线下面积分别为0.724、0.730、0.652、0.686、0.865、0.756、0.849、0.935,经过Z检验比较,MRI+SAA+TFF1联合起来诊断GM的诊断效能高于MRI、血清SAA、TFF1单独诊断(Z=2.264、3.756、2.864,P<0.05);MRI、SAA、TFF1、MRI联合血清SAA、TFF1水平Kappa值分别为0.660、0.587、0.623、0.804。结论MRI联合血清SAA、TFF1检测在辅助鉴别GM与NMBC中具有一定应用价值,可辅助鉴别及诊断乳腺疾病。Objective To explore the value of MRI perfusion imaging combined with serum amyloid A(SAA)and trefoil factor 1(TFF1)in the differentiation between granulomatous mastitis(GM)and nonmass breast cancer(NMBC).Methods A total of 112 patients who underwent breast MRI examination at Wuhan Hospital of Traditional Chinese Medicine from August 2019 to August 2023 were selected.Among them,54 patients had GM and 58 had NMBC,forming the GM group and NMBC group respectively.The expression levels of serum SAA and TFF1 were measured in both groups.Receiver operating characteristic(ROC)curves were used to analyze the efficacy of MRI perfusion imaging combined with SAA and TFF1 in distinguishing between GM and NMBC.Additionally,Kappa test was conducted to assess the consistency of pathological results.Results The Kep,Ktrans,CER,and EER values in the GM group were higher than those in the NMBC group,and the differences were statistically significant(P<0.05).SAA and TFF1 values in the GM group were lower than those in the NMBC group,and the difference was statistically significant(P<0.05).The ROC curve shows that the MRI perfusion parameters Kep,Ktrans,CER,EER values,as well as MRI,serum SAA and TFF1,MRI+SAA+TFF1 had area under the curve values of 0.724,0.730,0.652,0.686,0.865,0.756,0.849,and 0.935,respectively,for diagnosing GM.After Z⁃test comparison,the diagnostic efficacy of MRI combined with SAA and TFF1 in the diagnosis of GM was higher than that of MRI,serum SAA and TFF1 alone(Z=2.264,3.756,2.864,P<0.05).The Kappa values of serum SAA and TFF1 levels,MRI,SAA,TFF1 and MRI combined were 0.660,0.587,0.623 and 0.804,respectively.Conclusion MRI combined with serum SAA and TFF1 detection has a certain application value in differentiating between GM and NMBC.It can also help in the identification and diagnosis of breast diseases.

关 键 词：肉芽肿性乳腺炎 非肿块型乳腺癌 MRI灌注成像 血清淀粉样蛋白A 三叶因子1 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学] R655.8