不同症状精神分裂症患者血清NPTX2、Netrin⁃4水平差异及与认知功能的关系  

Differences in serum NPTX2 and Netrin⁃4 levels in patients with different symptoms of schizophrenia and their relationship with cognitive function

作　　者：张继涛 王东娜 袁红亮 刘乔 田美 ZHANG Jitao;WANG Dongna;YUAN Hongliang;LIU Qiao;TIAN Mei(Department of Substance Dependence,Hebei Province third military special care hospital,Baoding,Hebei,China,071000;Department of Clinical Laboratory,Hebei Qingyuan Maternal and Child Health Hospital,Baoding,Hebei,China,071100;Department of Clinical Laboratory,Beijing University of Chinese Medicine East Hospital Qinhuangdao Hospital/Qinhuangdao Hospital of Traditional Chinese Medicine,Qinhuangdao,Hebei,China,066000)

机构地区：[1]河北省第三荣军优抚医院物质依赖科,河北保定071000 [2]保定市清苑区妇幼保健院检验科,河北保定071100 [3]北京中医药大学东方医院秦皇岛医院/秦皇岛市中医医院检验科,河北秦皇岛066000

出　　处：《分子诊断与治疗杂志》2025年第1期188-191,196,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河北省重点研发计划项目(18277795D)。

摘　　要：目的探讨不同症状精神分裂症(SCH)患者血清神经元正五聚蛋白2(NPTX2)、轴突生长诱向因子4(Netrin⁃4)水平差异及与认知功能的关系。方法选取2019年1月至2023年12月于河北省第三荣军优抚医院就诊的148例SCH患者作为研究组,另选同期140名健康体检者作为对照组。采用阴阳性症状量表(PANSS)评估SCH患者的临床症状,并根据PANSS总分将148例SCH患者分为高分组和低分组。采用SCH认知功能成套测验(MCCB)评估认知功能,根据认知功能评估结果将患者分为障碍组和正常组。采用Spearman相关法探讨SCH患者血清NPTX2、Netrin⁃4与临床症状、认知功能的关系。结果研究组血清NPTX2、Netrin⁃4水平低于对照组,差异有统计学意义(P<0.05)。高分组阳性症状、阴性症状、一般病理症状、附加症状及PANSS总分均高于低分组,血清NPTX2、Netrin⁃4水平低于低分组,差异有统计学意义(P<0.05)。研究组MCCB认知功能中各项评分均低于对照组,差异有统计学意义(P<0.05)。认知障碍组患者血清NPTX2、Netrin⁃4水平低于正常组,差异有统计学意义(P<0.05)。SCH患者血清NPTX2与Netrin⁃4水平呈正相关(r=0.635,P<0.05)。SCH患者血清NPTX2、Netrin⁃4水平与PANSS得分均呈负相关,与MCCB得分呈正相关(均P<0.05)。结论血清NPTX2和Netrin⁃4水平在SCH患者不同症状群体间存在显著差异,NPTX2、Netrin⁃4降低与认知功能损害密切相关。Objective To investigate the differences of serum levels of neuronal pentaprotein 2(NPTX2)and axonal growth inducement factor 4(Netrin⁃4)in patients with different symptoms of schizophre⁃nia(SCH)and their relationship with cognitive function.Methods 148 SCH cases from January 2019 to De⁃cember 2023 were selected for the study group,and 140 healthy subjects for physical examination were chosen as the control group.The clinical symptoms of SCH cases were evaluated using PANSS,and the patients were divided into high and low groups based on the total score of PANSS.Cognitive function was assessed using the SCH cognitive function battery(MCCB).Patients were then categorized into impaired and normal groups based on the cognitive function assessment results.The correlation between serum NPTX2 and Netrin⁃4 in SCH pa⁃tients was determined using the Pearson correlation method,while the relationship between serum NPTX2 and Netrin⁃4 and clinical symptoms and cognitive function in SCH patients was determined using the Spearman cor⁃relation method.Results The serum levels of NPTX2 and Netrin⁃4 in the study group were lower compared with the control group(P<0.05).Positive symptom score,negative symptom score,general pathological symp⁃tom score,additional symptom score,and PANSS total score in the high group were higher compared with the low group(P<0.05).The levels of serum NPTX2 and Netrin⁃4 in the high group were lower compared with the low group(P<0.05).The scores of MCCB cognitive function in the study group were lower compared with the control group(P<0.05).The levels of serum NPTX2 and Netrin⁃4 in the cognitive impairment group were lower compared with the normal group(P<0.05).Serum NPTX2 was positively correlated with Netrin⁃4 levels in SCH patients(r=0.635,P<0.05).Both of them were negatively correlated with PANSS scores and positively corre⁃lated with MCCB scores in SCH patients(P<0.05).Conclusion There are significant differences in serum NPTX2 and Netrin⁃4 levels among SCH patients in diff

关 键 词：SCH 神经元正五聚蛋白2 轴突生长诱向因子4 临床症状 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]