间歇性Theta节律刺激对脑卒中失语症患者语言功能、认知功能及日常生活交流能力的影响  

Influence of intermittent Theta rhythm stimulation on language function,cognitive function and daily life communication ability in stroke patients with aphasia

作　　者：曾贞 王凯 张琴 冯芳芳 陆春华 Zeng Zhen;Wang Kai;Zhang Qin(Department of Neuralogical Rehablition,Shanghai No.4 Rehabilitation Hospital,Shanghai 200042,China)

机构地区：[1]上海市第四康复医院神经康复科,200042

出　　处：《中华保健医学杂志》2025年第1期99-102,共4页Chinese Journal of Health Care and Medicine

基　　金：上海市静安区卫生科研课题(2023US13)。

摘　　要：目的观察间歇性Theta节律刺激对脑卒中失语症患者语言功能、认知功能及日常生活交流能力的影响。方法前瞻性选取上海市第四康复医院2022年7月~2023年11月收治的70例脑卒中后非流利性失语症患者,采用简单随机法分为观察组和对照组,各35例。对照组给予cTBS交替假刺激干预,观察组给予cTBS交替iTBS刺激干预,共治疗4周。于治疗前、治疗4周及随访时(停止治疗1月)分别评估两组患者西方失语成套测验(WAB)、日常生活交流能力量表(CADL)评分、非语言性认知功能评估量表(NLCA)评分、视图命名测试情况,同时比较两组患者事件相关电位N400潜伏期与波幅差值。结果与对照组患者相比,观察组患者治疗4周、随访时的WAB评分更高,差异均有统计学意义(t=9.083、10.213,P<0.05)。治疗4周、随访时,观察组患者的CADL评分均高于对照组患者,差异均有统计学意义(t=6.431、7.044,P<0.05);治疗4周、随访时,观察组患者的NLCA评分均高于对照组患者,差异均有统计学意义(t=2.170、2.140,P<0.05)。观察组患者治疗4周、随访时的命名得分均高于对照组患者,差异均有统计学意义(t=2.341、2.653,P<0.05);观察组患者治疗4周、随访时的命名反应时间短于对照组患者,差异均有统计学意义(t=3.060、3.638,P<0.05)。与对照组患者相比,观察组患者治疗前与治疗4周、治疗前与随访时不同点位事件相关电位N400潜伏期与波幅差值均更高,差异均有统计学意义(P<0.05)。结论cTBS交替iTBS刺激可改善患者的神经电生理,促进语言功能、认知功能的恢复,提高日常生活交流能力。Objective To observe the influence of intermittent Theta rhythm stimulation on language function,cognitive function and daily life communication ability of stroke patients with aphasia.Methods A total of 70 patients with post-stroke nonfluent aphasia who met the inclusion criteria were prospectively selected from July 2022 to November 2023,and the patients were divided into control group and observation group by simple randomization method,with 35 cases in each group.The control group was given cTBS alternating false stimulation intervention,and the observation group was given cTBS alternating iTBS intervention,and both groups were treated for 4 weeks.The WAB,CADL score,NLCA score,and view naming test were assessed before treatment,4 weeks after treatment and at follow-up.The N400 latency and amplitude of event-related potentials were also detected in both groups.Results After 4 weeks of treatment and at follow-up,compared with the control group,the WAB score in the observation group was higher(t=9.083,10.213,P<0.05).The CADL score in the observation group was higher than that in the control group(t=7.044,2.653,P<0.05).The NLCA score in the observation group was higher than that in the control group(t=2.170,2.140,P<0.05).The naming score of view naming test in the observation group was higher than that in the control group(t=2.341,2.653,P<0.05).The naming reaction time of view naming test in the observation group was shorter(t=3.060,3.638,P<0.05).Compared with the control group,the differences of latency and amplitude of event-related potential N400 in the observation group before treatment and after 4 weeks of treatment,before treatment and at follow-up were higher in the observation group(P<0.05).Conclusion cTBS alternating iTBS stimulation can improve the neuroelectrophysiology of patients,promote the recovery of language function and cognitive function,and enhance the ability of daily life communication.

关 键 词：Theta爆发性经颅磁刺激 脑卒中 失语症 语言功能 认知功能 日常生活交流能力 

分 类 号：R743[医药卫生—神经病学与精神病学]