盐酸倍他司汀联合抗眩晕操治疗眩晕综合征对患者眩晕程度及血液流变学与血管内皮功能的影响  

Effect of betahistine hydrochloride combined with antivertigo exercise on vertigo degree,hemorheology and vascular endothelial function in patients with vertigo syndrome

作　　者：程顺好 朱正红 苏量 王国芳 吴景梅 Cheng Shunhao;Zhu Zhenghong;Su Liang(Department of Neurology,Xuancheng Central Hospital,Xuancheng 242000,China)

机构地区：[1]宣城市中心医院神经内科,242000

出　　处：《中华保健医学杂志》2025年第1期103-106,共4页Chinese Journal of Health Care and Medicine

基　　金：安徽省宣城市卫生健康科研项目(XCWJ2022028)。

摘　　要：目的研究盐酸倍他司汀联合抗眩晕操治疗因脑内缺血导致的眩晕综合征对患者眩晕程度及血液流变学与血管内皮功能的影响。方法前瞻性选取宣城市中心医院神经内科2022年1月~2024年2月收治的因脑内缺血导致的眩晕综合征患者160例,依据数字随机数表法分为联合组(n=80)和对照组(n=80),对照组采用盐酸倍他司汀片口服治疗,联合组在对照组的基础上进行抗眩晕操训练治疗。比较两组患者的临床疗效和治疗后6个月复发率;比较两组患者治疗前后的眩晕程度[眩晕症状评分简化量表(VSS-SF)、Berg平衡量表(BBS)、眩晕障碍量表(DHI)评分]、血液流变学[全血黏度低切(BVL)、中切(BVM)、高切(BVH)、血浆黏度及红细胞比积]、血管内皮功能[血清一氧化氮(NO)、内皮素-1(ET-1)水平]。结果治疗后,联合组临床治疗总有效率优于对照组,且复发率低于对照组,差异有统计学意义(χ^(2)=4.103、8.640,P<0.05)。治疗后,联合组患者VSS-SF、DHI均显著低于对照组,BBS评分显著高于对照组,差异有统计学意义(t=0.504、4.679、3.588,P<0.05);联合组患者BVL、BVM及BVH指标均显著低于对照组,差异有统计学意义(t=9.045、7.282、7.160,P<0.05);联合组患者ET-1显著低于对照组,NO水平显著高于对照组,差异有统计学意义(t=8.928、6.563,P<0.05)。结论采用盐酸倍他司汀联合抗眩晕操对因脑内缺血导致的眩晕综合征进行治疗具有显著疗效且治疗后复发率较低,可提高患者的平衡力、降低眩晕程度,改善患者血管内皮功能,降低其血液黏度,其改善效果优于单独使用盐酸倍他司汀治疗。Objective To investigate the effects of betahistine hydrochloride combined with anti-vertigo exercises on the severity of vertigo,hemorheology,and vascular endothelial function in patients with vertigo syndrome caused by intracerebral ischemia.Methods This study is a prospective study in which 160 patients with vertigo syndrome due to intracerebral ischemia were prospectively selected from the Department of Neurology in our hospital from January 2022 to February 2024.They were divided into a combination group(n=80)and a control group(n=80)based on a digital randomization table.The control group was treated with oral betahistine hydrochloride tablets,while the combination group received additional anti-vertigo exercise training.The clinical efficacy and 6-month recurrence rate were compared between the two groups.The severity of vertigo before and after treatment[Vertigo Symptom Scale-Short Form(VSS-SF),Berg Balance Scale(BBS),Dizziness Handicap Inventory(DHI)scores],hemorheology[blood viscosity at low shear rate(BVL),medium shear rate(BVM),high shear rate(BVH),plasma viscosity,and hematocrit],and vascular endothelial function[serum nitric oxide(NO),endothelin-1(ET-1)levels]were also compared.Results After treatment,the combination group showed a superior total effective rate in clinical treatment compared to the control group,and a lower recurrence rate(χ^(2)=4.103,8.640,P<0.05).The combination group had significantly lower VSS-SF,DHI,ET-1,BVL,BVM,and BVH indices than the control group(t=0.504,4.679,8.928,9.045,7.282,7.160,P<0.05),and significantly higher BBS scores and NO levels(t=3.588,6.563,P<0.05).Conclusion The treatment of vertigo syndrome caused by intracerebral ischemia with betahistine hydrochloride combined with anti-vertigo exercises is significantly effective with a lower recurrence rate after treatment.It can improve patients'balance,reduce the severity of vertigo,enhance vascular endothelial function,and decrease blood viscosity,with superior improvement outcomes compared to betahistine hydrochlori

关 键 词：眩晕综合征 盐酸倍他司汀 抗眩晕操 眩晕程度 血液流变学 血管内皮功能 

分 类 号：R74[医药卫生—神经病学与精神病学]