基于IL-6、SOD、NSE水平探究丁苯酞联合银杏叶在老年血管性痴呆患者中的治疗效果  

To explore the therapeutic effect of butylphthalein combined with ginkgo biloba in elderly patients with vascular dementia based on IL-6,SOD and NSE levels

作　　者：周佩莉 陈承 吴文倩 周皖舒 张勇 程峰 Zhou Peili;Chen Cheng;Wu Wenqian(Department of Geriatrics,the Second Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)

机构地区：[1]皖南医学院第二附属医院老年医学科,芜湖241001 [2]皖南医学院第二附属医院神经内科,芜湖241001 [3]皖南医学院第二附属医院药剂科,芜湖241001

出　　处：《中华保健医学杂志》2025年第1期107-110,共4页Chinese Journal of Health Care and Medicine

基　　金：皖南医学院校级重点科研项目(WK2021ZF22);安徽省高等学校自然科学研究项目(KJ2021A0831)。

摘　　要：目的探讨丁苯酞联合银杏叶对老年血管性痴呆患者白细胞介素-6(IL-6)、超氧化物歧化酶(SOD)以及脑组织神经元特异性烯醇化酶(NSE)水平的影响。方法选取2021年1月~2023年12月于皖南医学院第二附属医院进行诊治的116例老年血管性痴呆患者进行前瞻性研究。根据抽签法将患者随机分为观察组和对照组,各58例。对照组患者采用丁苯酞治疗,观察组患者采用丁苯酞联合银杏叶片治疗。比较两组患者的临床疗效、血清学指标(IL-6、SOD、NSE)水平、认知功能[简易智力状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)]、生活活动能力[日常生活活动能力量表(ADL)]及不良反应发生率。结果治疗后,两组患者的IL-6和NSE水平均较治疗前降低,而SOD水平较治疗前升高,且观察组患者的IL-6和NSE水平降低得更加明显,SOD水平升高得较为明显,差异均有统计学意义(P<0.05);观察组患者的IL-6和NSE水平低于对照组患者,SOD水平高于对照组患者,差异均有统计学意义(t=3.729、4.694、4.963,P<0.05)。治疗后,两组患者的MMSE和MoCA评分均升高,且观察组患者的MMSE评分、MoCA评分均高于对照组患者,差异均有统计学意义(t=9.497、4.609,P<0.05)。治疗后,两组患者的ADL评分均高于治疗前,且观察组患者的ADL评分高于对照组患者,差异有统计学意义(t=30.342,P<0.05)。观察组患者的不良反应总发生率为1.72%(1∕58),低于对照组患者的13.79%(8∕58),差异有统计学意义(χ^(2)=4.223,P<0.05)。结论银杏叶联合丁苯酞治疗老年血管性痴呆患者具有显著的效果,不仅可以减轻机体炎症、氧化反应,改善患者认知功能,提高SOD、NSE水平,降低IL-6水平,还可以进一步提高患者的生活活动能力,值得临床推广应用。Objective To investigate the impact of the combination of butylphthalide and Ginkgo biloba on the levels of interleukin-6(IL-6),superoxide dismutase(SOD),and neuron-specific enolase(NSE)in elderly patients with vascular dementia.Methods 116 patients with senile vascular dementia who were treated in our hospital from January 2021 to December 2023 were selected for prospective study.All patients were randomly divided into control group and observation group,58 cases in each group.Control group was treated with butylphthalein,observation group was treated with butylphthalein combined with ginkgo biloba leaves.The clinical efficacy,IL-6,SOD,NSE levels,cognitive function,activity of life and incidence of adverse reactions were compared between the two groups.Results There was no difference in the general data between the two groups(P>0.05).Post-treatment,both groups exhibited reduced levels of IL-6 and NSE,while SOD levels increased.Specifically,the observation group showed a more significant decrease in IL-6 and NSE levels,and a more pronounced increase in SOD levels(t=3.729,4.694,4.963,P<0.05).After treatment,the scores of MMSE and Montreal Cognitive Assessment Scale(MoCA)in both groups were increased,and the MMSE and MoCA scores in the observation group were higher than those in the control group(t=9.497,4.609,P=0.000).After treatment,the scores of Activities of daily living scale(ADL)of both groups were increased,and the ADL scores of observation group were significantly increased(t=30.342,P=0.000).The total incidence of adverse reactions in observation group(1.72%)was lower than that in control group(13.79%),and the difference was statistically significant(t=4.223,P=0.040).Conclusion Ginkgo biloba combined with butylphthalein has significant effects in the treatment of elderly patients with vascular dementia,which can reduce inflammation and oxidation reaction,improve cognitive function,increase SOD and NSE levels,reduce IL-6 levels,and further improve patients'life activity ability,which is worthy of clinical pr

关 键 词：丁苯酞 银杏叶 血管性痴呆 白细胞介素-6 超氧化物歧化酶 脑组织神经元特异性烯醇化酶 

分 类 号：R741[医药卫生—神经病学与精神病学]