和胃降逆方治疗慢性萎缩性胃炎伴肠上皮化生的临床研究  

Clinical Study of Hewei Jiangni Recipe in Treating Chronic Atrophic Gastritis with Intestinal Metaplasia

作　　者：丁伟亮 王玉芹 谭波 DING Wei-liang;WANG Yu-qin;TAN Bo(Linqu County Hospital of Traditional Chinese Medicine,Weifang 262600,China)

机构地区：[1]临朐县中医院,潍坊262600

出　　处：《中国合理用药探索》2025年第2期118-122,共5页Chinese Journal of Rational Drug Use

基　　金：潍坊市中医药科研立项项目(WFZYY2023-4-017)。

摘　　要：目的:探讨和胃降逆方对慢性萎缩性胃炎(CAG)伴肠上皮化生(IM)的临床疗效。方法:选取2023年10月1日~2024年9月30日期间某院肝胆脾胃科的48例住院患者作为研究对象,采用随机数字表法分为对照组和观察组,每组24例。两组均进行个人史、家族史、饮食生活习惯等方面的问卷调查,同时给予根除幽门螺杆菌、保护胃黏膜等基础治疗。对照组患者给予胃复春胶囊治疗,观察组患者给予和胃降逆方治疗,两组均治疗3个月。比较两组中医症候(上腹痛、腹胀、嗳气、反酸、纳差)积分、胃黏膜组织评分、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃蛋白酶原比值(PGR)、临床疗效及不良反应发生情况。结果:治疗后,两组患者各项中医症候积分均降低(P<0.05),且观察组低于对照组(P<0.05);各项胃黏膜组织评分均降低(P<0.05),且观察组低于对照组(P<0.05);PGⅠ水平均升高(P<0.05),且观察组高于对照组(P<0.05);PGⅡ水平均降低(P<0.05),但两组比较无统计学差异(P>0.05);观察组患者PGR较治疗前升高(P<0.05),且高于对照组(P<0.05)。观察组患者治疗总有效率(91.67%)高于对照组(75.00%,P<0.05)。治疗过程中未发现两组患者明显肝肾功能异常。结论:和胃降逆方可显著减轻CAG伴IM患者的临床症状,改善胃镜、病理评分及胃黏膜功能,且临床疗效确切。Objective:To investigate the clinical efficacy of Hewei Jiangni recipe in treating chronic atrophic gastritis(CAG)with intestinal metaplasia(IM).Methods:A total of 48 inpatients from the hepatobiliary,spleen and gastroenterology department of a hospital,admitted from October 1,2023 to September 30,2024 were selected and assigned to the control group and observation group by random number table method,with 24 patients in each group.Both groups underwent questionnaire surveys on personal history,family history,dietary and lifestyle habits,etc.,and were given basic treatments such as eradication of Helicobacter pylori and gastric mucosal protection.The control group was treated with Weifuchun capsule,and the observation group was treated with Hewei Jiangni recipe.Both groups were treated for 3 months.The traditional Chinese medicine(TCM)symptom(epigastric pain,abdominal distension,belching,acid regurgitation,poor appetite)scores,gastric mucosal tissue scores,pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),pepsinogen ratio(PGR),clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment,the TCM symptom scores were decreased in both groups(P<0.05),and the observation group showed lower scores compared to the control group(P<0.05).The gastric mucosal tissue scores were decreased in both groups(P<0.05),with the observation group showing lower scores than the control group(P<0.05).The level of PGⅠwas increased in both groups(P<0.05),with the observation group showing higher level than the control group(P<0.05).The level of PGⅡwas decreased in both groups(P<0.05),but there was no statistically significant difference between the two groups(P>0.05).The PGR in the observation group was higher than that before treatment(P<0.05),and higher than that in the control group(P<0.05).The total response rate in the observation group(91.67%)was higher than that in the control group(75.00%,P<0.05).No abnormal liver and kidney function was found in the two groups during treatment.Conclusion:Hewei J

关 键 词：和胃降逆方 慢性萎缩性胃炎 肠上皮化生 临床研究 中医药治疗 

分 类 号：R573.32[医药卫生—消化系统]