膳食补充剂在非小细胞肺癌患者中应用的Meta分析  

Meta-analysis of the application of dietary supplement in patients with non-small cell lung cancer

作　　者：李欣 马俊 谢占峰 刘芳 于澄 郭军鹏 杨焱[3] LI Xin;MAJun;XIE Zhanfeng;LIU Fang;YU Cheng;GUO Junpeng;YANG Yan(School of Clinical Medicine,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China;College of Traditional Chinese Medicine,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China;Third Department of Internal Medicine,Jilin Cancer Hospital,Changchun 130012,Jilin,China)

机构地区：[1]长春中医药大学临床医学院,长春130117 [2]长春中医药大学中医学院,长春130117 [3]吉林省肿瘤医院内三科,长春130012

出　　处：《癌症进展》2025年第2期138-145,共8页Oncology Progress

基　　金：吉林省科技发展计划项目(20210401061YY);吉林省卫生健康科技能力提升项目(2022JC047)。

摘　　要：目的系统评价膳食补充剂在非小细胞肺癌(NSCLC)患者中的应用效果。方法检索PubMed、Embase、Cochrane Library和Web of Science数据库中关于NSCLC患者使用膳食补充剂的研究,检索时间从建库至2024年4月。将NSCLC患者分为试验组(使用膳食补充剂)和对照组(未使用膳食补充剂),采用RevMan 5.2和Stata 15.0软件对两组患者的生存情况、不良反应发生情况、炎症反应指标、生理指标及营养摄入量进行Meta分析。结果试验组患者的无进展生存期(PFS)明显长于对照组,差异有统计学意义[加权均数差(WMD)=1.20,95%置信区间(CI):0.97~1.44,P﹤0.01];试验组患者的总生存率高于对照组,差异有统计学意义[风险比(HR)=1.27,95%CI:1.05~1.54,P=0.012)]。试验组患者2~3级食管炎发生率明显低于对照组,差异有统计学意义[比值比(OR)=0.17,95%CI:0.10~0.32,P﹤0.01]。试验组患者C反应蛋白(CRP)和白细胞介素-6(IL-6)水平均明显低于对照组,差异均有统计学意义[标准化均差(SMD)=-1.02,95%CI:-1.77~-0.27,P﹤0.01;WMD=-6.40,95%CI:-9.08~-3.72,P﹤0.01]。试验组患者体重减轻发生率明显低于对照组,差异有统计学意义(OR=0.11,95%CI:0.06~0.20,P﹤0.01);试验组患者体重变化优于对照组,差异有统计学意义(WMD=3.67,95%CI:0.38~6.96,P=0.029)。试验组患者能量和蛋白质摄入量均高于对照组,差异均有统计学意义(WMD=402.80,95%CI:249.01~556.59,P﹤0.01;WMD=18.00,95%CI:4.15~31.85,P=0.011)。结论使用膳食补充剂可改善NSCLC患者的生存情况,减少不良反应,降低炎症反应指标及体重减轻发生率,并增加能量和蛋白质的摄入量,有可能成为改善NSCLC患者预后的有效方法。Objective To systematically evaluate the efficacy of dietary supplement in patients with non-small cell lung cancer(NSCLC).Method Studies on dietary supplement use in patients with NSCLC were searched in PubMed,Embase,Cochrane Library and Web of Science databases from the establishment of the databases until April 2024.NSCLC patients were divided into experimental group(received dietary supplement)and control group(not received dietary supplement).Meta-analysis was performed on survival,adverse reactions,inflammatory response indicators,physiological indicators and nutrient intake of the two groups by using RevMan 5.2 and Stata 15.0 softwares.Result The progression-free survival(PFS)of experimental group was significantly longer than that of control group,and the difference was statistically significant[weighted mean difference(WMD)=1.20,95%confidence interval(CI):0.97-1.44,P<0.01].The overall survival rate of experimental group was higher than that of control group,and the difference was statistically significant[hazard ratio(HR)=1.27,95%CI:1.05-1.54,P=0.012].The incidence of grade 2 to 3 esophagitis in experimental group was significantly lower than that in control group,and the difference was statistically significant[odds ratio(OR)=0.17,95%CI:0.10-0.32,P<0.01].The levels of C-reactive protein(CRP)and interleukin-6(IL-6)in experimental group were significantly lower than those in control group,and the differences were statistically significant[standardized mean difference(SMD)=-1.02,95%CI:-1.77--0.27,P<0.01;WMD=-6.40,95%CI:-9.08~-3.72,P<0.01].The incidence of weight loss in experimental group was significantly lower than that in control group,and the difference was sta-tistically significant(OR=0.11,95%CI:0.06-0.20,P<0.01).The body weight change of experimental group was better than that of control group,and the difference was statistically significant(WMD=3.67,95%CI:0.38-6.96,P=0.029).The energy and protein intakes of experimental group were higher than those of control group,and the differences were statisti

关 键 词：膳食补充剂 非小细胞肺癌 预后 META分析 

分 类 号：R734.2[医药卫生—肿瘤]