多西他赛联合雄激素去势治疗在晚期前列腺癌患者中的应用  

Application of docetaxel combined with androgen castration in patients with advanced prostate cancer

作　　者：刘畅 刘志鹏 凌传江 LIU Chang;LIU Zhipeng;LING Chuanjiang(Department of Urology,the Second People’s Hospital of Aksu Region,Aksu 843000,Xinjiang,China)

机构地区：[1]阿克苏地区第二人民医院泌尿外科,新疆阿克苏843000

出　　处：《癌症进展》2025年第2期195-198,共4页Oncology Progress

摘　　要：目的探讨多西他赛联合雄激素去势治疗在晚期前列腺癌患者中的应用效果。方法将60例晚期前列腺癌患者根据治疗方式的不同分为去势组(n=30)和联合组(n=30)。去势组患者采取雄激素去势治疗,联合组患者在去势组的基础上联合多西他赛治疗。比较两组患者的临床疗效、血清肿瘤标志物[前列腺特异性抗原(PSA)、人激肽释放酶2(h K2)、微小RNA-221(miRNA-221)]、生活质量[欧洲癌症研究与治疗组织生命质量测定量表(EORTC QLQ-C30)]以及不良反应发生情况。结果联合组患者总有效率高于去势组,差异有统计学意义(P﹤0.05)。治疗后,两组患者血清PSA、hK2、miRNA-221水平均较治疗前降低,且联合组患者血清PSA、hK2、miRNA-221水平均低于去势组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者认知功能、躯体功能、社会功能、情绪功能、角色功能评分均较治疗前升高,且联合组患者认知功能、躯体功能、社会功能、情绪功能、角色功能评分均高于去势组,差异均有统计学意义(P﹤0.05)。两组患者不良反应总发生率比较,差异无统计学意义(P﹥0.05)。结论多西他赛联合雄激素去势治疗可降低晚期前列腺癌患者血清肿瘤标志物水平,改善患者生活质量,疗效较为显著。Objective To investigate the application effect of docetaxel combined with androgen castration in patients with advanced prostate cancer.Method A total of 60 patients with advanced prostate cancer were divided into castration group(n=30)and combined group(n=30)according to different treatment methods.The castration group was treated with androgen castration,and the combined group was treated with docetaxel on the basis of castration group.Clinical efficacy,serum tumor markers[prostate specific antigen(PSA),human kallikrein 2(hK2),microRNA-221(miRNA-221)],quality of life[European Organization for Research and Treatment of Cancer quality of life questionnaire core 30(EORTC QLQ-C30)]and the incidence of adverse reactions were compared between the two groups.Result The total effective rate of combined group was higher than that of castration group,the difference was statistically significant(P<0.05).After treatment,the levels of serum PSA,hK2 and miRNA-221 in two groups were lower than those before treatment,and the levels of serum PSA,hK2 and miRNA-221 in combined group were lower than those in castration group,the differences were statistically significant(P<0.05).After treatment,the scores of cognitive function,physical function,social function,emotional function and role function of two groups were higher than those before treatment,and the scores of cognitive function,physical function,social function,emotional function and role function of combined group were higher than those of castration group,the differences were statistically significant(P>0.05).Conclusion Docetaxel combined with androgen castration can reduce the levels of serum tumor markers and improve the quality of life in patients with advanced prostate cancer,and the curative effect is relatively remarkable.

关 键 词：晚期前列腺癌 多西他赛 雄激素 临床疗效 

分 类 号：R737.25[医药卫生—肿瘤]