经直肠超声造影检查联合血清前列腺特异性抗原检测对前列腺癌的诊断及预后预测价值  

Diagnostic and prognostic predictive value of contrast-enhanced transrectal ultrasound combined with serum prostate-specific antigen detection in prostate cancer

作　　者：万建平 周强 WAN Jianping;ZHOU Qiang(Department of Urology,the People’s Hospital of Lean,Fuzhou 344300,Jiangxi,China)

机构地区：[1]乐安县人民医院泌尿外科,江西抚州344300

出　　处：《癌症进展》2025年第2期236-239,共4页Oncology Progress

摘　　要：目的探讨经直肠超声造影(CE-TRUS)检查联合血清前列腺特异性抗原(PSA)检测对前列腺癌的诊断及预后预测价值。方法选取68例前列腺癌患者和60例前列腺良性增生患者,分别作为前列腺癌组和对照组,全部患者均进行CE-TRUS检查及血清PSA检测。对所有前列腺癌患者随访1年,根据随访结果分为复发转移组和未复发转移组。比较前列腺癌组和对照组、复发转移组和未复发转移组患者的CE-TRUS参数和血清PSA水平。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),分析CE-TRUS参数、血清PSA单独及联合检测对前列腺癌的诊断及预后预测价值。结果前列腺癌组患者显影时间、加速时间、达峰时间均明显短于对照组,绝对增强强度、血清PSA水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。CE-TRUS参数与血清PSA联合检测诊断前列腺癌的AUC和特异度分别为0.985、0.983,均高于各指标单独检测。68例前列腺癌患者中,复发转移19例,未复发转移49例。复发转移组患者显影时间、加速时间、达峰时间均明显短于未复发转移组,绝对增强强度、血清PSA水平均明显高于未复发转移组,差异均有统计学意义(P﹤0.01)。CE-TRUS参数与血清PSA联合检测预测前列腺癌患者预后的AUC、灵敏度、特异度分别为0.941、0.949、0.976,均高于各指标单独检测。结论前列腺癌患者血清PSA水平较高,CE-TRUS检查联合血清PSA检测能够提高前列腺癌的诊断价值,且有助于评估患者预后。Objective To investigate the diagnostic and prognostic predictive value of contrast-enhanced transrectal ultrasound(CE-TRUS)combined with serum prostate-specific antigen(PSA)detection in prostate cancer.Method Sixty-eight patients with prostate cancer and sixty patients with benign prostatic hyperplasia were selected as prostate cancer group and control group,respectively.CE-TRUS examination and serum PSA detection were performed in all patients.All patients with prostate cancer were followed up for 1 year and divided into recurrence and metastasis group and non-recurrence and metastasis group.The CE-TRUS parameters and serum PSA level were compared between prostate cancer group and control group,recurrence and metastasis group and non-recurrence and metastasis group.The receiver operating characteristic(ROC)curve was plotted,the area under the curve(AUC)was calculated,and the diagnostic and prognostic predictive value of CE-TRUS parameters and serum PSA single and combined detection in prostate cancer were analyzed.Result The development time,acceleration time and peak time in prostate cancer group were significantly shorter than those in control group,and the absolute enhancement intensity and serum PSA level were significantly higher than those in control group,the differences were statistically significant(P<0.01).The AUC and specificity of CE-TRUS parameters and serum PSA combined detection in diagnosis of prostate cancer were 0.985 and 0.983,respectively,which were higher than the single detection of each index.Among 68 patients with prostate cancer,19 patients had recurrence and metastasis,and 49 patients had no recurrence and metastasis.The development time,acceleration time and peak time in recurrence and metastasis group were significantly shorter than those in non-recurrence and metastasis group,and the absolute enhancement intensity and serum PSA level were significantly higher than those in non-recurrence and metastasis group,the differences were statistically significant(P<0.01).The AUC,sensitivity

关 键 词：前列腺癌 经直肠超声造影 前列腺特异性抗原 诊断 预后预测 

分 类 号：R737.25[医药卫生—肿瘤]