QLU-C10D量表在乳腺癌患者中测量属性的验证研究  

Validation of measurement attributes for QLU-C10D scale in breast cancer patients

作　　者：谷文 周澜 贾燕妮 黄卫东[1] GU Wen;ZHOU Lan;JIA Yanni;HUANG Weidong(The School of Health Management,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学卫生管理学院,哈尔滨150081

出　　处：《实用肿瘤学杂志》2025年第1期49-55,共7页Practical Oncology Journal

基　　金：国家自然科学基金(编号:72274045)。

摘　　要：目的本研究评估QLU-C10D量表在乳腺癌患者中的测量属性,为该工具在乳腺癌患者健康效用测量应用提供证据。方法自2022年7月开始,收集哈尔滨医科大学附属肿瘤医院及哈尔滨医科大学附属第一医院乳腺癌患者的资料,基于中国效用积分体系计算QLU-C10D量表和EQ-5D-5L量表的效用值。通过会聚效度和组间效度对首次收集的样本数据进行效度评估,并在治疗三个月后再次收集数据以评估QLU-C10D量表在乳腺癌患者中的反应性。结果在会聚效度方面,QLU-C10D量表与EQ-5D-5L量表之间理论相关维度的相关性高于无关维度,其中,QLU-C10D量表中的疼痛与EQ-5D-5L量表中的疼痛之间的相关性最高(r=0.546),而QLU-C10D量表中的睡眠与EQ-5D-5L量表中的自我照顾相关性最低(r=0.219)。组间效度中,QLU-C10D量表在所有分组(教育水平、居住地址、体检频次、经济压力和ECOG评分)中的相对效度(relative efficiency,RE)均大于1。在反应性方面,QLU-C10D量表能够有效反映乳腺癌患者在治疗后的健康状态变化,特别是在角色功能(ES=0.415,SRM=0.645)和肠道问题(ES=0.433,SRM=0.708)维度。结论QLU-C10D量表具有较好的会聚效度、组间效度和良好的反应性,是一种可用于乳腺癌患者的健康效用测量以及卫生技术评估研究的疾病特异性健康效用测量工具。Objective This study aimed to evaluate the measurement attributes of the QLU-C10D scale in breast cancer patients,and provide the evidence for the application of the tool in the measurement of health effectiveness of breast cancer patients.Methods Since July 2022,the data of breast cancer patients in Harbin Medical University Cancer Hospital and the First Affiliated Hospital of Harbin Medical University were collected,and the utility values for the QLU-C10D and EQ-5D-5L were calculated based on the Chinese utility scoring system.The validity of the first collected sample data was evaluated by convergent validity and known-group validity,The data were collected again three months after treatment to evaluate the responsiveness of QLU-C10D in breast cancer patients.Results In terms of convergent validity,the theoretical correlation dimension between the QLU-C10D and EQ-5D-5L scale was higher than that of irrelevant dimensions.Among them,the correlation between pain in QLU-C10D scale and pain in EQ-5D-5L scale was the highest(r=0.546),while the correlation between insomnia in QLU-C10D scale and self-care in EQ-5D-5L scale was the lowest(r=0.219).In terms of known-group validity,the QLU-C10D scale had a relative efficiency(RE)greater than 1 in all groups(education level,residential address,frequency of physical examinations,economic pressures,and ECOG score).In terms of responsiveness,the QLU-C10D scale could effectively reflect the changes in health status of breast cancer patients after treatment,especially in the dimensions of role function(ES=0.415,SRM=0.645)and bowel problems(ES=0.433,SRM=0.708).Conclusion The QLU-C10D scale has good convergent validity,known-group validity and good responsiveness.It is a disease-specific health utility measurement tool that can be used for health utility measurement of breast cancer patients and health technology evaluation research.

关 键 词：QLU-C10D量表 测量属性 乳腺癌 效度 反应性 

分 类 号：R737.9[医药卫生—肿瘤]