MEOX2在胶质瘤中的生物信息学特征及其临床意义  

Bioinformatics characteristics of MEOX2 in glioma and its clinical significance

作　　者：岳桂辰 赵光勇 李承龙 李勐[1] YUE Guichen;ZHAO Guangyong;LI Chenglong;LI Meng(Department of Neurosurgery,Binzhou Medical University Hospital,Shandong,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院神经外科,山东滨州256603

出　　处：《中国医药科学》2025年第4期8-12,共5页China Medicine And Pharmacy

基　　金：山东省医药卫生科技发展计划项目(2019WS323)。

摘　　要：目的探讨转录因子间充质蛋白2(MEOX2)在脑胶质瘤中的表达及其与临床特征和预后的关联,并分析其与免疫细胞浸润的相关性。方法本研究通过分析癌症基因组图谱(TCGA)和基因型组织表达(GTEx)数据库的正常组织数据,探讨了MEOX2在胶质瘤中的表达及其与临床病理特征的关联,并使用Kaplan-Meier、Cox回归和受试者操作特征曲线(ROC)评估其预后价值。此外,通过京都百科全书基因和基因组(KEGG)和基因本体论(GO)分析探究了MEOX2在胶质瘤中的作用机制,并结合TCGA与肿瘤免疫表型探索和资源(TIMER)数据库分析了其与免疫细胞浸润的相关性。结果MEOX2在多形性胶质母细胞瘤(GBM)中表达显著高于正常组织,与肿瘤分级、IDH状态及1q/19q状态相关。高表达MEOX2与总生存期相关,ROC曲线分析显示MEOX2具有较高的诊断价值。GO和KEGG富集分析揭示MEOX2与多种生物学过程和信号通路相关。TIMER数据库分析显示MEOX2与免疫微环境显著相关。结论MEOX2在胶质瘤组织中表达上调,与免疫细胞浸润相关,在肿瘤进展和患者不良预后中发挥关键作用。MEOX2可作为脑胶质瘤潜在的治疗靶点和预后指标。Objective To investigate the expression of mesenchyme homeobox 2(MEOX2)in glioma and its correlation with clinical features and prognosis,and analyze its correlation with immune cell infiltration.Methods By analyzing the normal tissue data of the cancer genome atlas(TCGA)and the genotype-tissue expression(GTEx)database,the expression of MEOX2 in glioma and its correlation with clinicopathological features were discussed in this research,and its prognostic value by Kaplan-Meier,Cox regression and receiver operating characteristic curve(ROC)were evaluated.In addition,the function mechanism of MEOX2 in glioma was explored through the analysis of Kyoto encyclopedia gene and genome(KEGG)and gene ontology(GO),and the correlation between MEOX2 and immune cell infiltration was analyzed by combining TCGA with tumor immunophenotype exploration and resource(TIMER)database.Results The expression of MEOX2 in glioblastoma multiforme(GBM)was significantly higher than that in normal tissues,which was related to tumor grade,IDH status and 1q/19q status.High expression of MEOX2 was related to overall survival,and ROC curve analysis showed that MEOX2 had high diagnostic value.GO and KEGG enrichment analysis revealed that MEOX2 was related to many biological processes and signal pathways.TIMER database analysis showed that MEOX2 was significantly related to immune microenvironment.Conclusion The up-regulation of MEOX2 expression in glioma tissue is related to the infiltration of immune cells,which plays a key role in tumor progression and poor prognosis of patients.MEOX2 can be used as a potential therapeutic target and prognostic in dex for glioma.

关 键 词：胶质瘤 生物信息学 生存预后 免疫浸润 转录因子间充质蛋白2 

分 类 号：R739.4[医药卫生—肿瘤]