结直肠癌患者中性粒-淋巴细胞比值、血小板-淋巴细胞比值、红细胞分布宽度变化及其对患者预后效果的判断价值  

Changes in ratio of neutrophil to lymphocyte,ratio of platelet to lymphocyte and red blood cell distribution width in patients with colorectal cancer and their judging value on the prognostic outcome of patients

作　　者：张艳 梁玉振 陶源 顾树江 ZHANG Yan;LIANG Yuzhen;TAO Yuan;GU Shujiang(Department of Pathology,Beijing Changping Traditional Chinese Medicine Hospital,Beijing 102200,China;Department of Clinical Laboratory,Beijing Changping Traditional Chinese Medicine Hospital,Beijing 102200,China;Department of Spleen and Stomach Disease,Beijing Changping Traditional Chinese Medicine Hospital,Beijing 102200,China)

机构地区：[1]北京市昌平区中医医院病理科,北京102200 [2]北京市昌平区中医医院检验科,北京102200 [3]北京市昌平区中医医院脾胃病科,北京102200

出　　处：《中国医药科学》2025年第4期106-109,163,共5页China Medicine And Pharmacy

摘　　要：目的研究结直肠癌患者中性粒-淋巴细胞比值(NLR)、血小板-淋巴细胞比值(PLR)、红细胞分布宽度(RDW)的变化情况及其对患者预后效果的判断价值。方法以回顾性研究方法,选取北京市昌平区中医医院2018年1月至2023年3月收治的120例结直肠癌患者(观察组)及100例健康体检对象(对照组)为研究对象。观察组根据预后效果分亚组(预后良好者为观察1组、预后不良者为观察2组)。比较不同组别结果差异。结果观察组的NLR、PLR、RDW较对照组高,差异有统计学意义(P<0.05)。观察组Ⅰ~Ⅱ期患者的NLR、PLR、RDW较Ⅲ期、Ⅳ期低,差异有统计学意义(P<0.05)。观察1组的NLR、PLR、RDW较观察2组低,差异有统计学意义(P<0.05);NLR、PLR、RDW升高以及Ⅲ~Ⅳ期、低分化、淋巴结转移是导致预后不良的危险因素(P<0.05)。结论结直肠癌患者病发后NLR、PLR、RDW水平显著上升且分期越高则水平越高,3个指标升高是导致结直肠癌患者预后不良的危险因素,对判断结直肠癌患者预后效果有积极价值。Objective To investigate the changes in ratio of neutrophil to lymphocyte(NLR),ratio of platelet to lymphocyte(PLR),and red blood cell distribution width(RDW)in patients with colorectal cancer and their prognostic value.Methods A retrospective study was conducted on 120 patients with colorectal cancer(the observation group)and 100 healthy individuals(the control group)admitted to Beijing Changping Traditional Chinese Medicine Hospital from January 2018 to March 2023.According to the prognostic effect of the observation group,the observation group was divided into subgroups(observation group 1 for those with good prognosis and observation group 2 for those with poor prognosis).The differences in results among different groups were compared.Results The NLR,PLR,and RDW of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).The NLR,PLR,and RDW of patients in stageⅠ-Ⅱin the observation group were lower than those in stagesⅢandⅣ,and the difference was statistically significant(P<0.05).The NLR,PLR,and RDW of observation group 1 were lower than those of observation group 2,and the difference was statistically significant(P<0.05).The increase of NLR,PLR and RDW,as well as stageⅢ-Ⅳ,low differentiation,and lymph node metastasis were risk factors leading to poor prognosis(P<0.05).Conclusion The levels of NLR,PLR and RDW in patients with colorectal cancer increase significantly after the onset of the disease,and the higher the stage,the higher the level.The increase of these three indexes is a risk factor leading to poor prognosis of patients with colorectal cancer,which has positive value in judging the prognosis of patients with colorectal cancer.

关 键 词：结直肠癌 中性粒-淋巴细胞比值 血小板-淋巴细胞比值 红细胞分布宽度 预后效果 淋巴结转移 判断价值 

分 类 号：R735.34[医药卫生—肿瘤]