中西医结合治疗未特指心境情感障碍的临床效果  

Clinical effect of integrated traditional Chinese and western medicine in the treatment of unspecified mood and affective disorders

作　　者：郭婧潭 王旭东 成文文 GUO Jingtan;WANG Xudong;CHENG Wenwen(Liaoning Provincial Institute of Basic Medicine,Shenyang 110000,China;不详)

机构地区：[1]辽宁省基础医学研究所,沈阳市110000 [2]丹东药业永合祥医院中医科,辽宁省丹东市118000

出　　处：《临床合理用药》2025年第6期10-13,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：辽宁省科学事业公益研究基金(软科学研究计划)项目(2023JH4/10700021);辽宁省教育厅2021年度科学研究经费项目(LJKZ1320)。

摘　　要：目的观察中西医结合治疗未特指心境情感障碍的临床效果。方法选取2021年3—10月丹东药业永合祥医院中医科收治的未特指心境情感障碍患者200例,按照随机数字表法分为联合组和西药组,每组100例。西药组在矫正治疗、脑电治疗、营养神经药物等常规治疗基础上采用阿普唑仑片治疗,联合组在西药组基础上增加中药方剂治疗,2组均治疗3个月。比较2组治疗前后抑郁自评量表(SDS)、焦虑自评量表(SAS)、健康调查量表36评分与神经递质水平[多巴胺(DA)、5-羟色胺(5-HT)、去甲肾上腺素(NE)],不良反应,随访1年复发率。结果治疗3个月后,2组SDS、SAS评分低于治疗前,且联合组低于西药组(P<0.01);2组身体健康、精神健康、精力、社会功能、情感功能评分高于治疗前,且联合组高于西药组(P<0.05或P<0.01);2组血清DA、5-HT、NE水平均低于治疗前,且联合组低于西药组(P<0.01);联合组不良反应总发生率低于西药组(4.00%vs.20.00%,χ^(2)=6.000,P=0.014);联合组随访1年复发率低于西药组(5.32%vs.15.79%,χ^(2)=6.000,P=0.014)。结论中西医结合治疗未特指心境情感障碍的疗效显著,可有效改善患者抑郁、焦虑等不良情绪,提高生活质量,抑制神经递质释放,具有较高的安全性,同时可降低复发率。Objective To observe the clinical effect of integrated traditional Chinese and western medicine in the treatment of unspecified mood and affective disorders.Methods A total of 200 patients with unspecified mood and affective disorders admitted to the department of Traditional Chinese Medicine of Yonghexiang Hospital of Dandong Pharmaceutical Co.,Ltd.from March to October 2021 were selected,and they were divided into the combination group and the western medicine group according to the random number table method,with 100 cases in each group.The western medicine group was treated with alprazolam tablets on the basis of conventional treatments such as corrective therapy,EEG therapy,and nutritional neurobasic drugs,and the combination group was treated with traditional Chinese medicine prescriptions on the basis of the western medicine group,and both groups were treated for 3 months.The scores of SDS,SAS,SF-36 and neurotransmitters(DA,5-HT,NE)before and after treatment,adverse reactions,and recurrence rate at 1 year of follow-up were compared between the two groups.Results After 3 months of treatment,the scores of SDS and SAS in the two groups were lower than those before treatment,and the combination group were lower than those in the western medicine group(P<0.01).The scores of physical health,mental health,energy,social function and emotional function in the two groups were higher than those before treatment,and the combination group were higher than those in the western medicine group(P<0.05 or P<0.01).The serum levels of DA,5-HT and NE in the two groups were lower than those before treatment,and the combination group were lower than those in the western medicine group(P<0.01).The total incidence of adverse reactions in the combination group was lower than that in the western medicine group(4.00%vs.20.00%,χ^(2)=6.000,P=0.014).The recurrence rate at 1 year of follow-up of the combination group was lower than that of the western medicine group(5.32%vs.15.79%,χ^(2)=6.000,P=0.014).Conclusion The integrated traditio

关 键 词：未特指心境情感障碍 中西医结合治疗 神经递质 不良反应 复发率 

分 类 号：R749[医药卫生—神经病学与精神病学]