帕金森病病人血清Sestrin2、sICAM-1水平与睡眠障碍的关系  

Serum levels of Sestrin2 and sICAM-1 in Parkinson's disease patients and their relationship with sleep disorders

作　　者：段洪波[1] 袁春晓[1] 刘晓龙 DUAN Hongbo;YUAN Chunxiao;LIU Xiaolong(Department 3 of Encephalopathy,East Campus,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou,Hebei 061000,China)

机构地区：[1]河北省沧州中西医结合医院东院区脑病三科,河北沧州061000

出　　处：《安徽医药》2025年第4期692-696,共5页Anhui Medical and Pharmaceutical Journal

基　　金：河北省中医药管理局中医药类科研计划课题项目(2021295)。

摘　　要：目的分析帕金森病(PD)病人血清应激诱导蛋白2(Sestrin2)、可溶性细胞间黏附分子-1(sICAM-1)水平及其与睡眠障碍的关系。方法选取河北省沧州中西医结合医院2020年1月至2023年2月收治的164例PD病人,根据帕金森病睡眠量表(PDSS)评分划分为睡眠障碍组(92例)和无睡眠障碍组(72例);酶联免疫吸附分析测定血清Sestrin2、sICAM-1水平;比较睡眠障碍组、无睡眠障碍组PD病人血清Sestrin2、sICAM-1水平及一般资料。Pearson法分析Sestrin2与sICAM-1水平相关性;Spear-man法分析Sestrin2、sICAM-1水平与匹兹堡睡眠质量指数(PSQI)相关性;logistic回归分析影响PD病人出现睡眠障碍的因素;受试者操作特征曲线(ROC曲线)分析血清Sestrin2、sICAM-1水平对PD病人出现睡眠障碍的预测价值。结果血清Sestrin2、sICAM-1水平睡眠障碍组[(11.73±1.67)μg/L、(2.66±0.37)μg/L]显著高于无睡眠障碍组[(7.32±1.48)μg/L、(1.95±0.32)μg/L](P<0.05)。睡眠障碍组PD病人超氧化物歧化酶、精神状况检查(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分[(102.35±20.85)U/mL、(26.93±3.02)分、(26.54±3.17)分]显著低于无睡眠障碍组PD病人[(128.16±20.92)U/mL、(28.12±3.05)分、(27.76±3.25)分],且睡眠障碍组丙二醛、PSQI显著高于无睡眠障碍组PD病人(P<0.05);相关性分析结果表明,Sestrin2与sICAM-1水平呈正相关(r=0.60,P<0.001);血清Sestrin2、sICAM-1水平与超氧化物歧化酶呈负相关,与丙二醛、PSQI呈正相关(P<0.05);logistic回归分析结果显示,超氧化物歧化酶、丙二醛、Sestrin2、sICAM-1为PD病人出现睡眠障碍的影响因素(P<0.05);ROC曲线结果表明,Sestrin2、sICAM-1水平联合预测PD病人出现睡眠障碍的AUC为0.99,显著高于Sestrin2(AUC=0.98)、sICAM-1(AUC=0.93)单独检测(Z_(Sestrin2-联合)=2.01,P=0.044,Z_(sICAM-1-联合)=3.13,P=0.002)。结论PD病人血清Sestrin2、sICAM-1水平较高,二者均为PD病人出现睡眠障碍的影响因素,Sestrin2、sICAM-1水平Objective To analyze the serum levels of Sestrin 2 and soluble intercellular adhesion molecule-1(sICAM-1)in patients with Parkinson's disease(PD)and their relationship with sleep disorders.Methods A total of 164 PD patients admitted to Cangzhou Hospital of Integrated TCM-WM·Hebei from January 2020 to February 2023 were collected,and according to the Parkinson's disease sleep scale(PDSS)score,they were grouped into a sleep disorder group(92 cases)and a non-sleep disorder group(72 cases),another 80 healthy individuals without sleep disorders were regarded as the control group;enzyme-linked immunosorbent assay was applied to measure serum levels of Sestrin2 and sICAM-1;the serum levels of Sestrin2 and sICAM-1,and general information were compared between the sleep disorder group and the non-sleep disorder group.Pearson method was applied to analyze the correlation between Sestrin2 and sICAM-1 levels;Spearman method was applied to analyze the correlation between the levels of Sestrin2 and sICAM-1 with Pittsburgh sleep quality index(PSQI);Logistic regression was applied to analyze the factors that affected the occurrence of sleep disorders in PD patients;ROC curve was applied to analyze the predictive value of serum Sestrin2 and sICAM-1 levels for sleep disorders in PD patients.Results The serum levels of Sestrin2 and sICAM-1 in the sleep disorder group[(11.73±1.67)μg/L,(2.66±0.37)μg/L]were significantly higher than those in non-sleep disorder group[(7.32±1.48)μg/L,(1.95±0.32)μg/L],and the differences were statistically significant(P<0.05).Malondialdehyde,the MMSE score and MoCA score of the sleep disorder group[(102.35±20.85)U/mL,(26.93±3.02)points,(26.54±3.17)points]were obviously lower than those of the non-sleep disorder group[(128.16±20.92)U/mL,(28.12±3.05)points,(27.76±3.25)points],while superoxide dismutase and the PSQI in sleep disorder group was obviously higher than that of the non sleep disorder group(P<0.05);the correlation analysis results showed a positive correlation between Sestrin2 and

关 键 词：帕金森病 入睡和睡眠障碍 应激诱导蛋白2 可溶性细胞间黏附分子-1 超氧化物歧化酶 

分 类 号：R74[医药卫生—神经病学与精神病学]