微波辅助低共熔溶剂合成3,5-二苯基吡啶  

Microwave-Assisted Synthesis of 3,5-Diphenylpyridine in Deep Eutectic Solvents

作　　者：闫浩 胡梦 周小强 田杨锴 王新颜 YAN Hao;HU Meng;ZHOU Xiaoqiang;TIAN Yangkai;WANG Xinyan(College of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang 712046,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;College of Chemistry and Materials Science,Weinan Normal University,Weinan 714099,China)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]北京中医药大学中药学院,北京102488 [3]渭南师范学院化学与材料学院,陕西渭南714099

出　　处：《化学与生物工程》2025年第3期33-36,共4页Chemistry & Bioengineering

基　　金：陕西省重点研发计划项目(2023-YBSF-278);咸阳市重点研发计划项目(L2022ZDYFSF054);中国博士后科学基金项目(2021M690474);陕西省教育厅科研计划项目(23JK0432)。

摘　　要：以苯乙醛为原料、乙酸铵为氮源,采用微波辅助低共熔溶剂法合成了3,5-二苯基吡啶,对其合成条件进行了优化,并通过^(1)HNMR、^(13)CNMR、EI-MS对其结构进行了表征。结果表明,3,5-二苯基吡啶的最优合成条件如下:苯乙醛用量为1.0 mmol、乙酸铵用量为1.2 mmol、以氯化胆碱-乙二醇(物质的量比1∶1)为低共熔溶剂、反应时间为90 s、微波功率为240 W,在此条件下,3,5-二苯基吡啶收率可达80.61%。Taking phenylacetaldehyde as a raw material,and ammonium acetate as a nitrogen source,we synthesized 3,5-diphenylpyridine by a microwave-assisted method in deep eutectic solvent.Moreover,we optimized the synthetic conditions,and characterized the structure by ^(1)HNMR,^(13)CNMR,and EI-MS.The results show that the optimum synthetic conditions of 3,5-diphenylpyridine are as follows:the dosage of phenylacetaldehyde is 1.0 mmol,the dosage of ammonium acetate is 1.2 mmol,choline chloride-ethylene glycol(molar ratio of 1∶1)is adopted as the deep eutectic solvent,the reaction time is 90 s,and the microwave power is 240 W.Under above conditions,the yield of 3,5-diphenylpyridine can reach 80.61%.

关 键 词：低共熔溶剂 苯乙醛 乙酸铵 微波辅助 3 5-二苯基吡啶 

分 类 号：TQ25[化学工程—有机化工]