A Group of Compositions for Ameliorating Acne Problems and Validation of Their Efficacy  

作　　者：Wang Jiajun Chen Dongzhi Xu Yongyu Ma Jieting 

机构地区：[1]Guangzhou Fandow Network Technology Co.,Ltd.,China

出　　处：《China Detergent & Cosmetics》2025年第1期64-72,共9页日用化学品科学(英文版)

摘　　要：To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining,and then 60 effective volunteers were selected for the efficacy measurement of topical acne elimination combinations+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers’facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the combination can inhibit the formation of P.acnes biofilm and will not completely kill P.acnes and will not disrupt the micro-ecological balance of the skin;3%and 5%acne combinations can reduce the biofilm of P.acnes by 61.3%and 61.6%respectively;after 4 weeks of continuous use,the area of acne lesions of the samples with 5%acne combinations decreased by 54.61%and the colour of acne lesions decreased by 54.61%compared with the area of acne lesions before the use of the combination.54.61%,acne lesion colour a^(*)decreased by 13.74%,and the subjects’self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The acne combination can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.

关 键 词：BIOFILM propionibacterium acnes anti-acne efficacy test 

分 类 号：R742.5[医药卫生—神经病学与精神病学] TQ658[医药卫生—临床医学]